Apbb1 - amyloid beta precursor protein binding family B member 1 Gene

Rattus norvegicus

Also known as FE65

Gene ID: 29722 | Gene type: protein coding

About Apbb1

Summary

Enables DNA-binding transcription factor binding activity; amyloid-beta binding activity; and Tau Protein binding activity. Involved in several processes, including histone H4 acetylation; negative regulation of cell cycle G1/S phase transition; and regulation of nucleobase-containing compound metabolic process. Located in several cellular components, including axon; dendritic spine; and synaptic membrane. Part of protein-containing complex. Is active in presynapse. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human APBB1 (amyloid beta precursor protein binding family B member 1). [provided by Alliance of Genome Resources, Apr 2022]

Apbb1 Products(1)

mRNA	Protein	Name
NM_080478.2	NP_536726.1	amyloid beta precursor protein binding family B member 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	9685356	RGD
enables amyloid-beta binding	IPI IPI: Inferred from physical interaction	9461550	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9407065	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	11441186	RGD
enables tau protein binding	IPI IPI: Inferred from physical interaction	15686969	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA repair-dependent chromatin remodeling	IMP IMP: Inferred from mutant phenotype	19282473	RGD
involved in negative regulation of cell cycle G1/S phase transition	IDA IDA: Inferred from direct assay	12089154	RGD
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12089154	RGD
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	18922798	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	25342469	RGD
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	24056087	RGD
involved in positive regulation of protein secretion	IMP IMP: Inferred from mutant phenotype	10075692	RGD
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11441186	RGD
involved in response to iron ion	IEP IEP: Inferred from expression pattern	18723004	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	16330549	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	18922798	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	16330549	RGD
located in growth cone	IDA IDA: Inferred from direct assay	19343227	RGD
located in growth cone filopodium	IDA IDA: Inferred from direct assay	12843239	RGD
located in growth cone lamellipodium	IDA IDA: Inferred from direct assay	12843239	RGD
located in main axon	IDA IDA: Inferred from direct assay	12843239	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	22429478	RGD
located in nucleus	IDA IDA: Inferred from direct assay	12089154	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	10075692	RGD
is active in postsynaptic density	IDA IDA: Inferred from direct assay	16330549	RGD
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	16330549	RGD
is active in presynapse	IDA IDA: Inferred from direct assay	12843239	RGD
located in presynaptic membrane	IDA IDA: Inferred from direct assay	16330549	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	11441186	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

amyloid beta precursor protein binding family B member 1

amyloid-beta A4 precursor protein-binding family B member 1

amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)

amyloid beta A4 precursor protein-binding family B member 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00804	APBB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00805	APBB1IP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Apbb1	NCBI	NCBI:322

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