Kcnab2 - potassium voltage-gated channel subfamily A regulatory beta subunit 2 Gene

Rattus norvegicus

Gene ID: 29738 | Gene type: protein coding

About Kcnab2

Summary

Enables aldo-keto reductase (NADP) activity; Potassium Channel regulator activity; and transmembrane transporter binding activity. Involved in several processes, including NADPH oxidation; myoblast differentiation; and regulation of protein localization to cell surface. Located in cytosol; juxtaparanode region of axon; and pinceau fiber. Is extrinsic component of cytoplasmic side of plasma membrane. Part of Potassium Channel complex. Colocalizes with microtubule. Orthologous to human KCNAB2 (potassium voltage-gated channel subfamily A regulatory beta subunit 2). [provided by Alliance of Genome Resources, Apr 2022]

Kcnab2 Products(1)

mRNA	Protein	Name
NM_017304.2	NP_059000.1	voltage-gated potassium channel subunit beta-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables aldo-keto reductase (NADPH) activity	IDA IDA: Inferred from direct assay	18672894	RGD
enables potassium channel regulator activity	IDA IDA: Inferred from direct assay	9763623	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10624965	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	10477520	RGD
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	8756417	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in NADPH oxidation	IDA IDA: Inferred from direct assay	18672894	RGD
involved in myoblast differentiation	IEP IEP: Inferred from expression pattern	12652645	RGD
involved in regulation of potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	9763623	RGD
involved in regulation of protein localization to cell surface	IMP IMP: Inferred from mutant phenotype	21357749	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	21357749	RGD
located in cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	23318870	RGD
located in cytosol	IDA IDA: Inferred from direct assay	21357749	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	24211303	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	24211303	RGD
located in juxtaparanode region of axon	IDA IDA: Inferred from direct assay	9334400	RGD
located in microtubule	IDA IDA: Inferred from direct assay	21357749	RGD
located in neuron projection	IDA IDA: Inferred from direct assay	23318870	RGD
located in pinceau fiber	IDA IDA: Inferred from direct assay	9334400	RGD
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	24211303	RGD
is active in postsynaptic density membrane	IMP IMP: Inferred from mutant phenotype	24211303	RGD
part of potassium channel complex	IDA IDA: Inferred from direct assay	9334400	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

voltage-gated potassium channel subunit beta-2

K(+) channel subunit beta-2	kv-beta-2
potassium channel, voltage gated shaker-related subfamily A regulatory beta subunit 2	potassium channel, voltage gated subfamily A regulatory beta subunit 2
potassium voltage-gated channel, shaker-related subfamil

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07104	KCNAB2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kcnab2	NCBI	NCBI:8514

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