Kcnab2 - potassium voltage-gated channel subfamily A regulatory beta subunit 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29738

Summary

Enables aldo-keto reductase (NADP) activity; Potassium Channel regulator activity; and transmembrane transporter binding activity. Involved in several processes, including NADPH oxidation; myoblast differentiation; and regulation of protein localization to cell surface. Located in cytosol; juxtaparanode region of axon; and pinceau fiber. Is extrinsic component of cytoplasmic side of plasma membrane. Part of Potassium Channel complex. Colocalizes with microtubule. Orthologous to human KCNAB2 (potassium voltage-gated channel subfamily A regulatory beta subunit 2). [provided by Alliance of Genome Resources, Apr 2022]

Kcnab2 Products (1)

mRNA Protein Name
NM_017304.2 NP_059000.1 voltage-gated potassium channel subunit beta-2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables aldo-keto reductase (NADPH) activity IDA
IDA: Inferred from direct assay
18672894 RGD
enables potassium channel regulator activity IDA
IDA: Inferred from direct assay
9763623 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
10624965 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
10477520 RGD
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
8756417 RGD
Biological Process GO Annotation Evidence References Source
involved in NADPH oxidation IDA
IDA: Inferred from direct assay
18672894 RGD
involved in myoblast differentiation IEP
IEP: Inferred from expression pattern
12652645 RGD
involved in regulation of potassium ion transmembrane transport IDA
IDA: Inferred from direct assay
9763623 RGD
involved in regulation of protein localization to cell surface IMP
IMP: Inferred from mutant phenotype
21357749 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
21357749 RGD
located in cytoplasmic side of plasma membrane IDA
IDA: Inferred from direct assay
23318870 RGD
located in cytosol IDA
IDA: Inferred from direct assay
21357749 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
24211303 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
24211303 RGD
located in juxtaparanode region of axon IDA
IDA: Inferred from direct assay
9334400 RGD
located in microtubule IDA
IDA: Inferred from direct assay
21357749 RGD
located in neuron projection IDA
IDA: Inferred from direct assay
23318870 RGD
located in pinceau fiber IDA
IDA: Inferred from direct assay
9334400 RGD
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
24211303 RGD
is active in postsynaptic density membrane IMP
IMP: Inferred from mutant phenotype
24211303 RGD
part of potassium channel complex IDA
IDA: Inferred from direct assay
9334400 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

voltage-gated potassium channel subunit beta-2

  • K(+) channel subunit beta-2

  • kv-beta-2

  • potassium channel, voltage gated shaker-related subfamily A regulatory beta subunit 2

  • potassium channel, voltage gated subfamily A regulatory beta subunit 2

  • potassium voltage-gated channel, shaker-related subfamil

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07104 KCNAB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kcnab2 NCBI NCBI:8514