Dguok - deoxyguanosine kinase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 297389

Summary

Predicted to enable deoxyadenosine kinase activity and deoxyguanosine kinase activity. Involved in ATP biosynthetic process; mitochondrial ATP synthesis coupled electron transport; and negative regulation of neuron projection development. Predicted to be active in cytosol and mitochondrion. Used to study mitochondrial DNA depletion syndrome 3. Human ortholog(s) of this gene implicated in autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 4; mitochondrial DNA depletion syndrome 3; Mitochondrial Metabolism disease; and portal hypertension. Orthologous to human DGUOK (deoxyguanosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Dguok Products (1)

mRNA Protein Name
NM_001106602.1 NP_001100072.1 deoxyguanosine kinase, mitochondrial

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in mitochondrial ATP synthesis coupled electron transport IMP
IMP: Inferred from mutant phenotype
30404003 RGD
involved in negative regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
18007665 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

deoxyguanosine kinase, mitochondrial

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03725 DGUOK Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dguok NCBI NCBI:1716