Dguok - deoxyguanosine kinase Gene

Rattus norvegicus

Gene ID: 297389 | Gene type: protein coding

About Dguok

Summary

Predicted to enable deoxyadenosine kinase activity and deoxyguanosine kinase activity. Involved in ATP biosynthetic process; mitochondrial ATP synthesis coupled electron transport; and negative regulation of neuron projection development. Predicted to be active in cytosol and mitochondrion. Used to study mitochondrial DNA depletion syndrome 3. Human ortholog(s) of this gene implicated in autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 4; mitochondrial DNA depletion syndrome 3; Mitochondrial Metabolism disease; and portal hypertension. Orthologous to human DGUOK (deoxyguanosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Dguok Products(1)

mRNA	Protein	Name
NM_001106602.1	NP_001100072.1	deoxyguanosine kinase, mitochondrial

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in mitochondrial ATP synthesis coupled electron transport	IMP IMP: Inferred from mutant phenotype	30404003	RGD
involved in negative regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	18007665	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

deoxyguanosine kinase, mitochondrial

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03725	DGUOK Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dguok	NCBI	NCBI:1716

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