VPREB3 - V-set pre-B cell surrogate light chain 3 Gene

Also Known as 8HS20; N27C7-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 29802

About VPREB3

Cytogenetic location: 22q11.23 Genomic coordinates (GRCh38): 22:23,752,743-23,754,425 (from NCBI)

This gene has 2 transcripts (splice variants), 111 orthologues and 93 paralogues. Biased expression in lymph node (RPKM 35.6), spleen (RPKM 23.3) and 5 other tissues.

Summary

The protein encoded by this gene is the human ortholog of the mouse VpreB3 (8HS20) protein, is thought to be involved in B-cell maturation, and may play a role in assembly of the pre-B cell receptor (pre-BCR). While the role of this protein in B-cell development has not yet been elucidated, studies with the chicken ortholog of this protein have found that when overexpressed, this protein localizes to the endoplasmic reticulum. The mouse ortholog of this protein has been shown to associate with membrane mu heavy chains early in the course of pre-B cell receptor biosynthesis. Expression of this gene has been observed in some lymphomas. [provided by RefSeq, Apr 2015]

VPREB3 Products (1)

mRNA Protein Name
NM_013378.3 NP_037510.1 pre-B lymphocyte protein 3 precursor

VPREB3 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (28 - 119)

  • 0
  • 100
  • 123 a.a.
Protein Preferred Names Protein Names

pre-B lymphocyte protein 3

  • pre-B lymphocyte 3

Related Diseases

Diseases Alias
Spondylometaphyseal Dysplasia, Sedaghatian Type

  • SMDS

  • Sedaghatian Chondrodysplasia

  • Spondylometaphyseal Dysplasia Sedaghatian Type

  • Congenital Lethal Metaphyseal Chondrodysplasia

  • Metaphyseal Chondrodysplasia, Congenital Lethal

  • Lethal Metaphyseal Dysplasia
Agammaglobulinemia 4, Autosomal Recessive

  • Agammaglobulinemia 4

  • AGM4

  • Agammaglobulinemia, Autosomal Recessive, Due To Blnk Defect

  • B Cell Linker Protein Deficiency

  • B-Cell Linker Protein Deficiency

  • Blnk Deficiency

  • Agammaglobulinemia Autosomal Recessive Due To Blnk Defect

  • Agammaglobulinemia, Type 4, Autosomal Recessive
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15670 VPREB3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus VPREB3 RGD RGD:1306807
Bos taurus VPREB3 VGNC VGNC:53929
Felis catus VPREB3 VGNC VGNC:66952
Canis familiaris VPREB3 VGNC VGNC:48272
Macaca mulatta VPREB3 VGNC VGNC:108070
Mus musculus VPREB3 MGD MGI:98938