2. Gene
  3. Dicer1 - dicer 1 ribonuclease III Gene

Dicer1 - dicer 1 ribonuclease III Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 299284 | Gene type: protein coding

About Dicer1

Summary

Predicted to enable RNA binding activity; Endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters; and protein domain specific binding activity. Predicted to contribute to pre-miRNA binding activity. Involved in several processes, including cellular response to oxygen-glucose deprivation; positive regulation of cell population proliferation; and positive regulation of Collagen biosynthetic process. Located in several cellular components, including dendrite; endoplasmic reticulum-Golgi intermediate compartment; and growth cone. Biomarker of middle cerebral artery infarction. Human ortholog(s) of this gene implicated in colorectal cancer; hepatocellular carcinoma; multinodular goiter; nephroma; and pleuropulmonary blastoma. Orthologous to human DICER1 (dicer 1, ribonuclease III). [provided by Alliance of Genome Resources, Apr 2022]

Dicer1 Products(10)

mRNA Protein Name
XM_039113358.1 XP_038969286.1 endoribonuclease Dicer isoform X1
XM_039113362.1 XP_038969290.1 endoribonuclease Dicer isoform X2
XM_039113361.1 XP_038969289.1 endoribonuclease Dicer isoform X1
XM_008764904.3 XP_008763126.1 endoribonuclease Dicer isoform X1
XM_039113363.1 XP_038969291.1 endoribonuclease Dicer isoform X2
XM_039113360.1 XP_038969288.1 endoribonuclease Dicer isoform X1
XM_039113364.1 XP_038969292.1 endoribonuclease Dicer isoform X2
XM_039113359.1 XP_038969287.1 endoribonuclease Dicer isoform X1
XM_017594505.2 XP_017449994.1 endoribonuclease Dicer isoform X4
XM_039113365.1 XP_038969293.1 endoribonuclease Dicer isoform X3
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
23239824 RGD
involved in cellular response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
23239824 RGD
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
26294080 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
23239824 RGD
involved in positive regulation of collagen biosynthetic process IMP
IMP: Inferred from mutant phenotype
24337369 RGD
involved in positive regulation of endothelial cell migration IMP
IMP: Inferred from mutant phenotype
23239824 RGD
involved in positive regulation of endothelial cell-matrix adhesion via fibronectin IMP
IMP: Inferred from mutant phenotype
23239824 RGD
involved in positive regulation of establishment of endothelial barrier IMP
IMP: Inferred from mutant phenotype
23239824 RGD
involved in positive regulation of hepatic stellate cell proliferation IMP
IMP: Inferred from mutant phenotype
24337369 RGD
involved in positive regulation of vascular endothelial cell proliferation IMP
IMP: Inferred from mutant phenotype
23239824 RGD
Cellular Component GO Annotation Evidence Reference Source
located in axon IDA
IDA: Inferred from direct assay
16723529 RGD
located in dendrite IDA
IDA: Inferred from direct assay
17888888 RGD
located in endoplasmic reticulum-Golgi intermediate compartment IDA
IDA: Inferred from direct assay
17888888 RGD
located in growth cone IDA
IDA: Inferred from direct assay
16723529 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

endoribonuclease Dicer

Dicer1, Dcr-1 homolog

dicer 1, ribonuclease type III

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03766 DICER1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dicer1 NCBI NCBI:23405