Abhd17a - abhydrolase domain containing 17A, depalmitoylase Gene

Rattus norvegicus

Also known as Fam108a; upf0227; Fam108a1; RGD1359682

Gene ID: 299617 | Gene type: protein coding

About Abhd17a

Summary

Enables palmitoyl-(protein) hydrolase activity. Involved in several processes, including negative regulation of protein localization to microtubule; positive regulation of protein localization to endosome; and protein depalmitoylation. Located in plasma membrane; postsynaptic density; and recycling endosome membrane. Is active in glutamatergic synapse. Is anchored component of postsynaptic density membrane and anchored component of postsynaptic recycling endosome membrane. Orthologous to human ABHD17A (abhydrolase domain containing 17A, depalmitoylase). [provided by Alliance of Genome Resources, Apr 2022]

Abhd17a Products(1)

mRNA	Protein	Name
NM_001006983.1	NP_001006984.1	alpha/beta hydrolase domain-containing protein 17A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables palmitoyl-(protein) hydrolase activity	IDA IDA: Inferred from direct assay	27307232	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of protein localization to microtubule	IMP IMP: Inferred from mutant phenotype	28521134	RGD
involved in positive regulation of protein localization to endosome	IMP IMP: Inferred from mutant phenotype	28521134	RGD
involved in protein depalmitoylation	IDA IDA: Inferred from direct assay	27307232	RGD
involved in regulation of postsynapse organization	IDA IDA: Inferred from direct assay	27307232	RGD
involved in regulation of postsynapse organization	IEP IEP: Inferred from expression pattern	27307232	RGD
involved in regulation of postsynapse organization	IMP IMP: Inferred from mutant phenotype	27307232	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	27307232	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	27307232	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	27307232	RGD
located in postsynaptic density	IDA IDA: Inferred from direct assay	27307232	RGD
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	27307232	RGD
is active in postsynaptic density membrane	IMP IMP: Inferred from mutant phenotype	27307232	RGD
is active in postsynaptic recycling endosome membrane	IDA IDA: Inferred from direct assay	27307232	RGD
is active in postsynaptic recycling endosome membrane	IMP IMP: Inferred from mutant phenotype	27307232	RGD
located in recycling endosome membrane	IDA IDA: Inferred from direct assay	27307232	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

alpha/beta hydrolase domain-containing protein 17A

abhydrolase domain-containing protein 17A	abhydrolase domain-containing protein FAM108A
family with sequence similarity 108, member A1	protein ABHD17A

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00091	ABHD17A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Abhd17a	NCBI	NCBI:81926

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