Pcsk1n - proprotein convertase subtilisin/kexin type 1 inhibitor Gene

Also Known as KEP; PEN; Pan3; SAAS; bLEN; lLEN; PEN19; PEN20; SAASCT; proSAAS

Species: Mus musculus

Gene Type: protein coding
Gene ID: 30052

Summary

Enables serine-type endopeptidase inhibitor activity. Acts upstream of or within peptide hormone processing; response to cold; and response to dietary excess. Located in extracellular space; secretory granule; and trans-Golgi network. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and sensory organ. Orthologous to human PCSK1N (proprotein convertase subtilisin/kexin type 1 inhibitor). [provided by Alliance of Genome Resources, Apr 2022]

Pcsk1n Products (1)

mRNA Protein Name
NM_013892.3 NP_038920.2 proSAAS precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
27117253 MGI
enables serine-type endopeptidase inhibitor activity IDA
IDA: Inferred from direct assay
10632593 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within peptide hormone processing IDA
IDA: Inferred from direct assay
10632593 MGI
acts upstream of or within response to cold IDA
IDA: Inferred from direct assay
16631141 MGI
acts upstream of or within response to dietary excess IDA
IDA: Inferred from direct assay
16631141 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
10632593 MGI
located in secretory granule IDA
IDA: Inferred from direct assay
10632593 MGI
located in trans-Golgi network IDA
IDA: Inferred from direct assay
10632593 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

proSAAS

  • IA-4

  • basic protein IA-4

  • big PEN LEN

  • big SAAS

  • granin-like neuroendocrine peptide

  • little LEN

  • little SAAS

  • pancreas protein 3

  • pro-SAAS

  • proprotein convertase 1 inhibitor

  • protein serine alanine alanine serine

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10171 PCSK1N Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pcsk1n NCBI NCBI:27344