Pcsk1n - proprotein convertase subtilisin/kexin type 1 inhibitor Gene

Mus musculus

Also known as KEP; PEN; Pan3; SAAS; bLEN; lLEN; PEN19; PEN20; SAASCT; proSAAS

Gene ID: 30052 | Gene type: protein coding

About Pcsk1n

Summary

Enables serine-type endopeptidase inhibitor activity. Acts upstream of or within peptide hormone processing; response to cold; and response to dietary excess. Located in extracellular space; secretory granule; and trans-Golgi network. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and sensory organ. Orthologous to human PCSK1N (proprotein convertase subtilisin/kexin type 1 inhibitor). [provided by Alliance of Genome Resources, Apr 2022]

Pcsk1n Products(1)

mRNA	Protein	Name
NM_013892.3	NP_038920.2	proSAAS precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	27117253	MGI
enables serine-type endopeptidase inhibitor activity	IDA IDA: Inferred from direct assay	10632593	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within peptide hormone processing	IDA IDA: Inferred from direct assay	10632593	MGI
acts upstream of or within response to cold	IDA IDA: Inferred from direct assay	16631141	MGI
acts upstream of or within response to dietary excess	IDA IDA: Inferred from direct assay	16631141	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	10632593	MGI
located in secretory granule	IDA IDA: Inferred from direct assay	10632593	MGI
located in trans-Golgi network	IDA IDA: Inferred from direct assay	10632593	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

proSAAS

IA-4	basic protein IA-4
big PEN LEN	big SAAS
granin-like neuroendocrine peptide	little LEN
little SAAS	pancreas protein 3
pro-SAAS	proprotein convertase 1 inhibitor
protein serine alanine alanine serine

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10171	PCSK1N Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pcsk1n	NCBI	NCBI:27344

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