Crb1 - crumbs cell polarity complex component 1 Gene

About Crb1

Summary

Predicted to enable calcium ion binding activity. Predicted to be involved in establishment or maintenance of epithelial cell apical/basal polarity and heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Predicted to act upstream of with a negative effect on cellular protein localization. Predicted to act upstream of or within several processes, including detection of light stimulus involved in visual perception; eye morphogenesis; and neurogenesis. Located in microvillus and photoreceptor inner segment. Human ortholog(s) of this gene implicated in pigmented paravenous chorioretinal atrophy and retinal disease (multiple). Orthologous to human CRB1 (crumbs cell polarity complex component 1). [provided by Alliance of Genome Resources, Apr 2022]