Nisch - nischarin Gene

Also Known as I-1; I1R; IR1

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 306255

Summary

Predicted to enable identical protein binding activity; Integrin binding activity; and protein kinase binding activity. Involved in several processes, including glucose metabolic process; norepinephrine secretion; and regulation of GABAergic synaptic transmission. Predicted to be located in several cellular components, including intercellular bridge; microtubule cytoskeleton; and nucleoplasm. Predicted to be active in cytoplasm. Used to study hypertension. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human NISCH (nischarin). [provided by Alliance of Genome Resources, Apr 2022]

Nisch Products (2)

mRNA	Protein	Name
NM_001376918.1	NP_001363847.1	nischarin isoform 1
NM_001409024.1	NP_001395953.1	nischarin isoform 2

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	References	Source
involved in glucose metabolic process	IMP IMP: Inferred from mutant phenotype	15028595	RGD
involved in norepinephrine secretion	IMP IMP: Inferred from mutant phenotype	15028598	RGD
involved in regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	14975931	RGD
involved in regulation of synaptic transmission, GABAergic	IMP IMP: Inferred from mutant phenotype	16467528	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
nischarin	I-1 receptor candidate protein imidazoline receptor 1 imidazoline receptor I-1 imidazoline-1 receptor

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09309	NISCH Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nisch	NCBI	NCBI:11188