Sall1 - spalt-like transcription factor 1 Gene

Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and beta-catenin binding activity. Predicted to be involved in several processes, including animal organ development; negative regulation of ectoderm development; and regulation of transcription, DNA-templated. Predicted to act upstream of or within several processes, including limb morphogenesis; metanephric nephron morphogenesis; and nervous system development. Predicted to be located in chromocenter; cytoplasm; and heterochromatin. Predicted to be part of NuRD complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Townes-Brocks syndrome and middle lobe syndrome. Orthologous to human SALL1 (spalt like transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]