Tomm40 - translocase of outer mitochondrial membrane 40 Gene

Rattus norvegicus

Also known as OM38; TOM40

Gene ID: 308416 | Gene type: protein coding

About Tomm40

Summary

Enables cation channel activity; preprotein binding activity; and protein transmembrane transporter activity. Involved in positive regulation of apoptotic process; protein insertion into mitochondrial membrane; and protein targeting to mitochondrion. Located in mitochondrial outer membrane. Is integral component of mitochondrial outer membrane. Part of mitochondrial outer membrane translocase complex. Human ortholog(s) of this gene implicated in cerebral infarction. Orthologous to human TOMM40 (translocase of outer mitochondrial membrane 40). [provided by Alliance of Genome Resources, Apr 2022]

Tomm40 Products(1)

mRNA	Protein	Name
NM_212520.2	NP_997685.2	mitochondrial import receptor subunit TOM40 homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables monoatomic cation channel activity	IDA IDA: Inferred from direct assay	15347672	RGD
enables preprotein binding	IDA IDA: Inferred from direct assay	15347672	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	19401463	RGD
enables protein transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	18687331	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	18687331	RGD
involved in protein insertion into mitochondrial membrane	IMP IMP: Inferred from mutant phenotype	18687331	RGD
involved in protein targeting to mitochondrion	IDA IDA: Inferred from direct assay	10980201	RGD
involved in protein targeting to mitochondrion	IMP IMP: Inferred from mutant phenotype	15347672	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	10980201	RGD
part of mitochondrial outer membrane translocase complex	IDA IDA: Inferred from direct assay	10980201	RGD
located in mitochondrion	IDA IDA: Inferred from direct assay	10980201	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

mitochondrial import receptor subunit TOM40 homolog

mitochondrial outer membrane protein of 38 kDa	outer membrane protein 38 kDa
translocase of outer membrane 40 kDa subunit homolog	translocase of outer mitochondrial membrane 40 homolog

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14882	TOMM40 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14883	TOMM40L Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tomm40	NCBI	NCBI:10452

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