Foxe3 - forkhead box E3 Gene

Also Known as dyl; rct; FREAC8

Species: Mus musculus

Gene Type: protein coding

Gene ID: 30923

Summary

Enables sequence-specific DNA binding activity. Involved in camera-type eye development; negative regulation of lens fiber cell differentiation; and positive regulation of lens epithelial cell proliferation. Acts upstream of or within camera-type eye development; cell development; and positive regulation of epithelial cell proliferation. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo ectoderm; eye; and heart. Used to study congenital aphakia. Human ortholog(s) of this gene implicated in anterior segment dysgenesis; anterior segment dysgenesis 2; cataract 34 multiple types; and thoracic aortic aneurysm. Orthologous to human FOXE3 (forkhead box E3). [provided by Alliance of Genome Resources, Apr 2022]

Foxe3 Products (1)

mRNA	Protein	Name
NM_015758.3	NP_056573.1	forkhead box protein E3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11980846	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within camera-type eye development	IMP IMP: Inferred from mutant phenotype	11309658	MGI
acts upstream of or within cell development	IMP IMP: Inferred from mutant phenotype	16199865	MGI
involved in ciliary body morphogenesis	IMP IMP: Inferred from mutant phenotype	17064680	MGI
involved in cornea development in camera-type eye	IMP IMP: Inferred from mutant phenotype	17064680	MGI
acts upstream of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	16199865	MGI
acts upstream of or within eye development	IMP IMP: Inferred from mutant phenotype	10652278	MGI
involved in iris morphogenesis	IMP IMP: Inferred from mutant phenotype	17064680	MGI
involved in lens development in camera-type eye	IMP IMP: Inferred from mutant phenotype	17064680	MGI
involved in negative regulation of lens fiber cell differentiation	IMP IMP: Inferred from mutant phenotype	10652278	MGI
acts upstream of or within positive regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	16199865	MGI
involved in positive regulation of lens epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	10652278	MGI
involved in trabecular meshwork development	IMP IMP: Inferred from mutant phenotype	17064680	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	17064680	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
forkhead box protein E3	Rinshoken cataract dysgenetic lens

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05048	FOXE3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Foxe3	NCBI	NCBI:2301