2. Gene
  3. Fig4 - FIG4 phosphoinositide 5-phosphatase Gene

Fig4 - FIG4 phosphoinositide 5-phosphatase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Sac3; Kiaa0274; RGD1311375

Gene ID: 309855 | Gene type: protein coding

About Fig4

Summary

Enables phosphatidylinositol bisphosphate Phosphatase activity; phosphatidylinositol-3-phosphatase activity; and phosphatidylinositol-4-phosphate Phosphatase activity. Involved in positive regulation of neuron projection development. Colocalizes with Golgi apparatus; endoplasmic reticulum; and recycling endosome. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4J; Yunis-Varon syndrome; amyotrophic lateral sclerosis type 11; and bilateral parasagittal parieto-occipital polymicrogyria. Orthologous to human FIG4 (FIG4 phosphoinositide 5-phosphatase). [provided by Alliance of Genome Resources, Apr 2022]

Fig4 Products(1)

mRNA Protein Name
NM_001047096.1 NP_001040561.1 polyphosphoinositide phosphatase
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables phosphatidylinositol bisphosphate phosphatase activity IDA
IDA: Inferred from direct assay
17909536 RGD
enables phosphatidylinositol-3-phosphate phosphatase activity IDA
IDA: Inferred from direct assay
17909536 RGD
enables phosphatidylinositol-4-phosphate phosphatase activity IDA
IDA: Inferred from direct assay
17909536 RGD
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
17909536 RGD
Cellular Component GO Annotation Evidence Reference Source
located in recycling endosome IDA
IDA: Inferred from direct assay
17909536 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

polyphosphoinositide phosphatase

Sac domain-containing inositol phosphatase 3

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04944 FIG4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22170 Fig4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fig4 NCBI NCBI:9896