2. Gene
  3. Nphp4 - nephrocystin 4 Gene

Nphp4 - nephrocystin 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 313749 | Gene type: protein coding

About Nphp4

Summary

Predicted to be involved in negative regulation of canonical Wnt signaling pathway; positive regulation of bicellular tight junction assembly; and protein localization to ciliary transition zone. Predicted to act upstream of or within several processes, including flagellated sperm motility; photoreceptor cell maintenance; and photoreceptor cell outer segment organization. Located in ciliary basal body. Human ortholog(s) of this gene implicated in Joubert syndrome 4; Senior-Loken syndrome; congenital heart disease; nephronophthisis; and nephronophthisis 4. Orthologous to human NPHP4 (nephrocystin 4). [provided by Alliance of Genome Resources, Apr 2022]

Nphp4 Products(1)

mRNA Protein Name
NM_001037650.2 NP_001032739.2 nephrocystin-4
Gene Ontology
  • Cellular Component
Cellular Component GO Annotation Evidence Reference Source
located in ciliary basal body IDA
IDA: Inferred from direct assay
17558407 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nephrocystin-4

nephronophthisis 4 (juvenile) homolog

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09485 NPHP4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nphp4 NCBI NCBI:261734