Kif5a - kinesin family member 5A Gene

Rattus norvegicus

Gene ID: 314906 | Gene type: protein coding

About Kif5a

Summary

Enables scaffold protein binding activity. Involved in several processes, including axonal transport; cellular response to ethanol; and forebrain development. Located in several cellular components, including P-body; central region of growth cone; and perikaryon. Part of Kinesin complex. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; hereditary spastic paraplegia 10; multiple sclerosis; prostate cancer; and rheumatoid arthritis. Orthologous to human KIF5A (Kinesin family member 5A). [provided by Alliance of Genome Resources, Apr 2022]

Kif5a Products(1)

mRNA	Protein	Name
NM_212523.1	NP_997688.1	kinesin heavy chain isoform 5A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14600269	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	17202468	RGD
enables scaffold protein binding	IDA IDA: Inferred from direct assay	17202468	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in anterograde axonal protein transport	IMP IMP: Inferred from mutant phenotype	23576431	RGD
involved in cellular response to ethanol	IEP IEP: Inferred from expression pattern	25022897	RGD
involved in cellular response to nerve growth factor stimulus	IEP IEP: Inferred from expression pattern	8963445	RGD
involved in cerebral cortex development	IEP IEP: Inferred from expression pattern	9349526	RGD
involved in hippocampus development	IEP IEP: Inferred from expression pattern	9349526	RGD
involved in neuron development	IEP IEP: Inferred from expression pattern	9349526	RGD
involved in response to rotenone	IEP IEP: Inferred from expression pattern	23263842	RGD
involved in retrograde neuronal dense core vesicle transport	IGI IGI: Inferred from genetic interaction	28426968	RGD
involved in thalamus development	IEP IEP: Inferred from expression pattern	9349526	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in P-body	IDA IDA: Inferred from direct assay	23487039	RGD
located in apical dendrite	IDA IDA: Inferred from direct assay	9349526	RGD
located in axon	IDA IDA: Inferred from direct assay	17202468	RGD
located in central region of growth cone	IDA IDA: Inferred from direct assay	17202468	RGD
located in dendrite	IDA IDA: Inferred from direct assay	22355657	RGD
part of kinesin complex	IDA IDA: Inferred from direct assay	17202468	RGD
located in microtubule	IDA IDA: Inferred from direct assay	17202468	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	9349526	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

kinesin heavy chain isoform 5A

NKHC	kinesin heavy chain neuron-specific 1
neuronal kinesin heavy chain

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07289	KIF5A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kif5a	NCBI	NCBI:3798

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