Kif5a - kinesin family member 5A Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 314906

Summary

Enables scaffold protein binding activity. Involved in several processes, including axonal transport; cellular response to ethanol; and forebrain development. Located in several cellular components, including P-body; central region of growth cone; and perikaryon. Part of Kinesin complex. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; hereditary spastic paraplegia 10; multiple sclerosis; prostate cancer; and rheumatoid arthritis. Orthologous to human KIF5A (Kinesin family member 5A). [provided by Alliance of Genome Resources, Apr 2022]

Kif5a Products (1)

mRNA Protein Name
NM_212523.1 NP_997688.1 kinesin heavy chain isoform 5A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14600269 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
17202468 RGD
enables scaffold protein binding IDA
IDA: Inferred from direct assay
17202468 RGD
Biological Process GO Annotation Evidence References Source
involved in anterograde axonal protein transport IMP
IMP: Inferred from mutant phenotype
23576431 RGD
involved in cellular response to ethanol IEP
IEP: Inferred from expression pattern
25022897 RGD
involved in cellular response to nerve growth factor stimulus IEP
IEP: Inferred from expression pattern
8963445 RGD
involved in cerebral cortex development IEP
IEP: Inferred from expression pattern
9349526 RGD
involved in hippocampus development IEP
IEP: Inferred from expression pattern
9349526 RGD
involved in neuron development IEP
IEP: Inferred from expression pattern
9349526 RGD
involved in response to rotenone IEP
IEP: Inferred from expression pattern
23263842 RGD
involved in retrograde neuronal dense core vesicle transport IGI
IGI: Inferred from genetic interaction
28426968 RGD
involved in thalamus development IEP
IEP: Inferred from expression pattern
9349526 RGD
Cellular Component GO Annotation Evidence References Source
located in P-body IDA
IDA: Inferred from direct assay
23487039 RGD
located in apical dendrite IDA
IDA: Inferred from direct assay
9349526 RGD
located in axon IDA
IDA: Inferred from direct assay
17202468 RGD
located in central region of growth cone IDA
IDA: Inferred from direct assay
17202468 RGD
located in dendrite IDA
IDA: Inferred from direct assay
22355657 RGD
part of kinesin complex IDA
IDA: Inferred from direct assay
17202468 RGD
located in microtubule IDA
IDA: Inferred from direct assay
17202468 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
9349526 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

kinesin heavy chain isoform 5A

  • NKHC

  • kinesin heavy chain neuron-specific 1

  • neuronal kinesin heavy chain

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07289 KIF5A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kif5a NCBI NCBI:3798