2. Gene
  3. Mtmr2 - myotubularin related protein 2 Gene

Mtmr2 - myotubularin related protein 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 315422 | Gene type: protein coding

About Mtmr2

Summary

Predicted to enable identical protein binding activity; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity; and phosphatidylinositol-3-phosphatase activity. Involved in several processes, including dendritic spine maintenance; negative regulation of excitatory postsynaptic potential; and regulation of vesicle-mediated transport. Located in several cellular components, including dendritic spine; postsynaptic density; and synaptic vesicle. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4B1. Orthologous to human MTMR2 (myotubularin related protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Mtmr2 Products(1)

mRNA Protein Name
NM_001108123.1 NP_001101593.1 myotubularin-related protein 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
20410104 RGD
Biological Process GO Annotation Evidence Reference Source
involved in dendritic spine maintenance IMP
IMP: Inferred from mutant phenotype
20410104 RGD
involved in negative regulation of endocytosis IMP
IMP: Inferred from mutant phenotype
20410104 RGD
involved in negative regulation of excitatory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
20410104 RGD
involved in negative regulation of receptor catabolic process IMP
IMP: Inferred from mutant phenotype
20410104 RGD
involved in negative regulation of receptor internalization IMP
IMP: Inferred from mutant phenotype
20410104 RGD
involved in positive regulation of early endosome to late endosome transport IMP
IMP: Inferred from mutant phenotype
20410104 RGD
Cellular Component GO Annotation Evidence Reference Source
located in axon IDA
IDA: Inferred from direct assay
20410104 RGD
located in cytosol IDA
IDA: Inferred from direct assay
20410104 RGD
located in dendrite IDA
IDA: Inferred from direct assay
20410104 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
20410104 RGD
located in postsynaptic density IDA
IDA: Inferred from direct assay
20410104 RGD
located in synaptic membrane IDA
IDA: Inferred from direct assay
20410104 RGD
located in synaptic vesicle IDA
IDA: Inferred from direct assay
20410104 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

myotubularin-related protein 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08789 MTMR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mtmr2 NCBI NCBI:8898