Apba1 - amyloid beta (A4) precursor protein binding, family A, member 1 Gene

Mus musculus

Also known as X11; Mint; Mint1; Lin-10; Urop11; X11alpha; 6430513E09Rik

Gene ID: 319924 | Gene type: protein coding

About Apba1

Summary

Predicted to enable PDZ domain binding activity; amyloid-beta binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in regulation of synaptic vesicle exocytosis. Acts upstream of or within several processes, including amino acid transport; in utero embryonic development; and intracellular protein transport. Located in glutamatergic synapse and presynaptic active zone membrane. Is active in Schaffer collateral - CA1 synapse. Is expressed in central nervous system and dorsal root ganglion. Orthologous to human APBA1 (amyloid beta precursor protein binding family A member 1). [provided by Alliance of Genome Resources, Apr 2022]

Apba1 Products(1)

mRNA	Protein	Name
NM_177034.3	NP_796008.2	amyloid-beta A4 precursor protein-binding family A member 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16186258	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within chemical synaptic transmission	IGI IGI: Inferred from genetic interaction	17167098	MGI
acts upstream of or within chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	17167098	MGI
acts upstream of or within establishment of localization in cell	IGI IGI: Inferred from genetic interaction	17167098	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	17167098	MGI
acts upstream of or within gamma-aminobutyric acid secretion	IMP IMP: Inferred from mutant phenotype	17167098	MGI
acts upstream of or within glutamate secretion	IGI IGI: Inferred from genetic interaction	17167098	MGI
acts upstream of or within in utero embryonic development	IGI IGI: Inferred from genetic interaction	17167098	MGI
acts upstream of or within intracellular protein transport	IPI IPI: Inferred from physical interaction	9822620	MGI
acts upstream of or within locomotory behavior	IGI IGI: Inferred from genetic interaction	17167098	MGI
acts upstream of or within multicellular organism growth	IGI IGI: Inferred from genetic interaction	17167098	MGI
involved in presynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	12547917	MGI
involved in presynaptic modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	12547917	MGI
acts upstream of or within regulation of gene expression	IGI IGI: Inferred from genetic interaction	17167098	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	12547917	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	12547917	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	10971649	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	17167098	MGI
located in membrane	IDA IDA: Inferred from direct assay	18054859	MGI
is active in presynaptic active zone membrane	IDA IDA: Inferred from direct assay	10971649	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

amyloid-beta A4 precursor protein-binding family A member 1

UROP11-110	adapter protein X11alpha
mint-1	neuron-specific X11 protein
neuronal Munc18-1-interacting protein 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00802	APBA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W751932	Carboxy-EG6-undecanethiol		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Apba1	NCBI	NCBI:320

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