Apba1 - amyloid beta (A4) precursor protein binding, family A, member 1 Gene

Also Known as X11; Mint; Mint1; Lin-10; Urop11; X11alpha; 6430513E09Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 319924

Summary

Predicted to enable PDZ domain binding activity; amyloid-beta binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in regulation of synaptic vesicle exocytosis. Acts upstream of or within several processes, including amino acid transport; in utero embryonic development; and intracellular protein transport. Located in glutamatergic synapse and presynaptic active zone membrane. Is active in Schaffer collateral - CA1 synapse. Is expressed in central nervous system and dorsal root ganglion. Orthologous to human APBA1 (amyloid beta precursor protein binding family A member 1). [provided by Alliance of Genome Resources, Apr 2022]

Apba1 Products (1)

mRNA Protein Name
NM_177034.3 NP_796008.2 amyloid-beta A4 precursor protein-binding family A member 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16186258 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within chemical synaptic transmission IGI
IGI: Inferred from genetic interaction
17167098 MGI
acts upstream of or within chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
17167098 MGI
acts upstream of or within establishment of localization in cell IGI
IGI: Inferred from genetic interaction
17167098 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
17167098 MGI
acts upstream of or within gamma-aminobutyric acid secretion IMP
IMP: Inferred from mutant phenotype
17167098 MGI
acts upstream of or within glutamate secretion IGI
IGI: Inferred from genetic interaction
17167098 MGI
acts upstream of or within in utero embryonic development IGI
IGI: Inferred from genetic interaction
17167098 MGI
acts upstream of or within intracellular protein transport IPI
IPI: Inferred from physical interaction
9822620 MGI
acts upstream of or within locomotory behavior IGI
IGI: Inferred from genetic interaction
17167098 MGI
acts upstream of or within multicellular organism growth IGI
IGI: Inferred from genetic interaction
17167098 MGI
involved in presynaptic modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
12547917 MGI
involved in presynaptic modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
12547917 MGI
acts upstream of or within regulation of gene expression IGI
IGI: Inferred from genetic interaction
17167098 MGI
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
12547917 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
12547917 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
10971649 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
17167098 MGI
located in membrane IDA
IDA: Inferred from direct assay
18054859 MGI
is active in presynaptic active zone membrane IDA
IDA: Inferred from direct assay
10971649 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

amyloid-beta A4 precursor protein-binding family A member 1

  • UROP11-110

  • adapter protein X11alpha

  • mint-1

  • neuron-specific X11 protein

  • neuronal Munc18-1-interacting protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00802 APBA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W751932 Carboxy-EG6-undecanethiol / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Apba1 NCBI NCBI:320