Col8a2 - collagen, type VIII, alpha 2 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 329941

Summary

Predicted to be an extracellular matrix structural constituent. Acts upstream of or within camera-type eye morphogenesis and epithelial cell proliferation. Predicted to be located in basement membrane and extracellular region. Predicted to be part of Collagen trimer. Predicted to be active in extracellular matrix and extracellular space. Is expressed in blood vessel; cornea endothelium; genitourinary system; and heart. Used to study Fuchs' endothelial dystrophy. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy and posterior polymorphous corneal dystrophy 2. Orthologous to human COL8A2 (Collagen type VIII alpha 2 chain). [provided by Alliance of Genome Resources, Apr 2022]

Col8a2 Products (1)

mRNA Protein Name
NM_199473.2 NP_955767.1 collagen alpha-2(VIII) chain precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within camera-type eye morphogenesis IGI
IGI: Inferred from genetic interaction
16051690 MGI
acts upstream of or within endothelial cell proliferation IGI
IGI: Inferred from genetic interaction
16051690 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

collagen alpha-2(VIII) chain

  • endothelial collagen

  • procollagen, type VIII, alpha 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02999 COL8A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Col8a2 NCBI NCBI:1296