Dixdc1 - DIX domain containing 1 Gene

Also Known as Ccd1; Ccd1CL; mKIAA1735; Ccd1BbetaL; Ccd1Abeta1L; Ccd1BalphaL; Ccd1Aalpha1L; 4930563F16Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 330938

Summary

Enables protein domain specific binding activity. Involved in several processes, including forebrain development; negative regulation of neuron differentiation; and regulation of Cytoskeleton organization. Located in cytosol. Is expressed in several structures, including autonomic nervous system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human DIXDC1 (DIX domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]

Dixdc1 Products (3)

mRNA	Protein	Name
NM_001311069.1	NP_001297998.1	dixin isoform 2
NM_001374656.1	NP_001361585.1	dixin isoform 3
NM_178118.2	NP_835219.1	dixin isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20624590	MGI
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	15579909	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	20624590	MGI
involved in cell proliferation in forebrain	IMP IMP: Inferred from mutant phenotype	20624590	MGI
involved in cerebral cortex cell migration	IMP IMP: Inferred from mutant phenotype	20624590	MGI
involved in cerebral cortex radially oriented cell migration	IMP IMP: Inferred from mutant phenotype	20624590	MGI
involved in forebrain ventricular zone progenitor cell division	IMP IMP: Inferred from mutant phenotype	20624590	MGI
involved in modification of postsynaptic actin cytoskeleton	IDA IDA: Inferred from direct assay	27829159	MGI
involved in modification of postsynaptic actin cytoskeleton	IMP IMP: Inferred from mutant phenotype	27829159	MGI
involved in negative regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	20624590	MGI
involved in positive regulation of Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	20624590	MGI
involved in regulation of actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	20624590	MGI
involved in regulation of microtubule cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	20624590	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in cytosol	IDA IDA: Inferred from direct assay	21189423	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	27829159	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	27829159	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	27829159	MGI
is active in postsynapse	IDA IDA: Inferred from direct assay	27829159	MGI
is active in postsynapse	IEP IEP: Inferred from expression pattern	27829159	MGI
is active in postsynapse	IMP IMP: Inferred from mutant phenotype	27829159	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
dixin	DIX domain-containing protein 1 coiled-coil protein DIX1 coiled-coil-DIX1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03785	DIXDC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dixdc1	NCBI	NCBI:85458