ZC3H12D - zinc finger CCCH-type containing 12D Gene

Also Known as TFL; p34; MCPIP4; C6orf95; dJ281H8.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 340152

About ZC3H12D

Cytogenetic location: 6q25.1 Genomic coordinates (GRCh38): 6:149,446,795-149,485,014 (from NCBI)

This gene has 5 transcripts (splice variants), 128 orthologues and 6 paralogues. Biased expression in lymph node (RPKM 4.6), appendix (RPKM 3.5) and 11 other tissues.

Summary

Predicted to enable endoribonuclease activity and mRNA binding activity. Involved in negative regulation of G1/S transition of mitotic cell cycle and negative regulation of cell growth. Located in P-body and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ZC3H12D Products (1)

mRNA Protein Name
NM_207360.3 NP_997243.2 probable ribonuclease ZC3H12D

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
26134560 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of G1/S transition of mitotic cell cycle IDA
IDA: Inferred from direct assay
19531561 GOA
involved in negative regulation of cell growth IDA
IDA: Inferred from direct assay
19531561 GOA
Cellular Component GO Annotation Evidence References Source
located in P-body IDA
IDA: Inferred from direct assay
24415781 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
19531561 GOA
located in nucleus IDA
IDA: Inferred from direct assay
19531561 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZC3H12D Protein Structure

RNase_Zc3h12a

RNase_Zc3h12a: Zc3h12a-like Ribonuclease NYN domain (89 - 243)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 527 a.a.
Protein Preferred Names Protein Names

probable ribonuclease ZC3H12D

  • Zinc finger CCCH domain-containing protein 12D

Related Diseases

Diseases Alias
Follicular Lymphoma

  • Lymphoma, Follicular

  • Lymphoma Follicular

  • Brill-Symmers' Disease

  • Large Cell Follicular Non-Hodgkin Lymphoma

  • Diffuse Follicle Centre Lymphoma

  • Diffuse Follicular Lymphoma Nos

  • Follicular Nodular Non-Hodgkin Lymphoma, Unspecified

  • Follicular Large Cell Cleaved Or Noncleaved Lymphoma

  • Large Cell Follicular Noncleaved Lymphoma

  • Follicular Lymphoma With Or Without Diffuse Areas

  • Histiocytic Follicular Lymphoma

  • Histiocytic Nodular Lymphoma

  • Histiocytic Nodular Malignant Lymphoma

  • Large Cell Follicular Lymphoma

  • Large Cell Noncleaved Follicular Lymphoma

  • Large Cell Noncleaved Follicular Malignant Lymphoma

  • Nodular Reticulum Cell Sarcoma

  • Noncleaved Follicular Lymphoma
Lymphoma

  • Lymphoid Cancer

  • Lymphomas

  • Lymphoid Cancers

  • Lymphoid Neoplasm

  • Lymphoma Nos

  • Nhl - [Non-Hodgkin Lymphoma]

  • Non-Hodgkin Lymphoma

  • Non-Hodgkin Lymphoma, Nos

  • Non-Hodgkin Malignant Lymphoma Nos
Diffuse Large B-Cell Lymphoma

  • Dlbcl

  • Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

  • Large B-Cell Diffuse Lymphoma

  • Lymphoma, Large B-Cell, Diffuse

  • Dlbcl - [Diffuse Large B-Cell Lymphoma]

  • Diffuse Large Beta Cell Lymphoma
Eastern Equine Encephalitis

  • Eee

  • Neuroinvasive Eastern Equine Encephalitis Virus Infection

  • Eastern Equine Encephalomyelitis

  • Encephalomyelitis, Eastern Equine

  • Triple E

  • Eastern Equine Encephalitis Virus Infection

  • Neuroinvasive Eastern Equine Encephalitis Virus Disease

  • Eee - [Eastern Equine Encephalitis]
Drug-Induced Lupus Erythematosus

  • Dile

  • Dil

  • Drug-Induced Systemic Lupus Erythematosus
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15987 ZC3H12D Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21269 Zc3h12d Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27787 Zc3h12d Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ZC3H12D VGNC VGNC:102555
Bos taurus ZC3H12D VGNC VGNC:37100
Canis familiaris ZC3H12D VGNC VGNC:54006
Macaca mulatta ZC3H12D VGNC VGNC:83972
Mus musculus ZC3H12D MGD MGI:3045313
Rattus norvegicus ZC3H12D RGD RGD:1597152
Others ZC3H12D NCBI