Tbx1 - T-box transcription factor 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 360737

Summary

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including animal organ development; regulation of transcription by RNA polymerase II; and vasculature development. Predicted to act upstream of or within several processes, including hard palate development; otic vesicle morphogenesis; and positive regulation of secondary heart field cardioblast proliferation. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in DiGeorge syndrome; tetralogy of Fallot; and velocardiofacial syndrome. Orthologous to human TBX1 (T-box transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Tbx1 Products (1)

mRNA Protein Name
NM_001108322.1 NP_001101792.1 T-box transcription factor TBX1

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in negative regulation of muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
31982878 RGD
involved in negative regulation of receptor signaling pathway via JAK-STAT IMP
IMP: Inferred from mutant phenotype
31982878 RGD
involved in positive regulation of cardiac muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
31982878 RGD
involved in positive regulation of cell cycle G1/S phase transition IMP
IMP: Inferred from mutant phenotype
31982878 RGD
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
31982878 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

T-box transcription factor TBX1

  • T-box 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14270 TBX1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20824 Tbx1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20980 Litaf Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27338 Tbx1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tbx1 NCBI NCBI:6899