Nfatc3 - nuclear factor of activated T-cells 3 Gene

Rattus norvegicus

Also known as NFAT4

Gene ID: 361400 | Gene type: protein coding

About Nfatc3

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in positive regulation of transcription, DNA-templated. Located in cytosol and nucleus. Orthologous to human NFATC3 (nuclear factor of activated T cells 3). [provided by Alliance of Genome Resources, Apr 2022]

Nfatc3 Products(1)

mRNA	Protein	Name
NM_001108447.2	NP_001101917.1	nuclear factor of activated T-cells, cytoplasmic 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	30980393	RGD
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	19538478	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	15016802	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	30980393	RGD
involved in positive regulation of cardiac muscle hypertrophy	IMP IMP: Inferred from mutant phenotype	30980393	RGD
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19538478	RGD
involved in protein import into nucleus	IDA IDA: Inferred from direct assay	21273244	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19538478	RGD
located in nucleus	IDA IDA: Inferred from direct assay	19538478	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

nuclear factor of activated T-cells, cytoplasmic 3

T cell transcription factor NFAT4

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N1353	Rhamnocitrin	Inhibitor	99.67%	Unkown
HY-P10889	CNI103	Inhibitor	99.56%	Unkown
HY-RS09241	NFATC3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nfatc3	NCBI	NCBI:4775

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