Derl1 - derlin 1 Gene

Predicted to enable several functions, including enzyme binding activity; misfolded protein binding activity; and signal recognition particle binding activity. Predicted to be involved in several processes, including ERAD pathway; endoplasmic reticulum unfolded protein response; and protein destabilization. Predicted to act upstream of or within cellular response to unfolded protein and retrograde protein transport, ER to cytosol. Predicted to be located in early endosome; endoplasmic reticulum quality control compartment; and late endosome. Predicted to be integral component of membrane. Predicted to be part of Derlin-1 retrotranslocation complex; Derlin-1-VIMP complex; and Hrd1p ubiquitin Ligase ERAD-L complex. Predicted to be integral component of endoplasmic reticulum membrane. Orthologous to human DERL1 (derlin 1). [provided by Alliance of Genome Resources, Apr 2022]