2. Gene
  3. Selenot - selenoprotein T Gene

Selenot - selenoprotein T Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 365802 | Gene type: protein coding

About Selenot

Summary

This gene encodes a selenoprotein, containing a selenocysteine (Sec) residue at the active site. Sec is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is localized in the endoplasmic reticulum. It belongs to the SelWTH family that possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif found in several redox active proteins. Studies in rat indicate a role for this gene in the regulation of calcium homeostasis and smooth muscle contraction. High induction of this gene is also associated with ontogenetic and regenerative processes in nervous, endocrine, and metabolic tissues. A pseudogene of this locus has been identified on chromosome 4. [provided by RefSeq, Aug 2017]

Selenot Products(1)

mRNA Protein Name
NM_001014253.3 NP_001014275.2 thioredoxin reductase-like selenoprotein T precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables thioredoxin-disulfide reductase (NADPH) activity IDA
IDA: Inferred from direct assay
26866473 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular oxidant detoxification IDA
IDA: Inferred from direct assay
26866473 RGD
involved in positive regulation of cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
18198219 RGD
involved in positive regulation of growth hormone secretion IMP
IMP: Inferred from mutant phenotype
18198219 RGD
Cellular Component GO Annotation Evidence Reference Source
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
18198219 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

thioredoxin reductase-like selenoprotein T

thioredoxin reductase-like enzyme

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12643 SELENOT Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Selenot NCBI NCBI:51714