2. Gene
  3. Nkx2-2 - NK2 homeobox 2 Gene

Nkx2-2 - NK2 homeobox 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 366214 | Gene type: protein coding

About Nkx2-2

Summary

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in optic nerve development; response to glucose; and response to progesterone. Located in nucleus. Biomarker of demyelinating disease. Orthologous to human NKX2-2 (NK2 homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]

Nkx2-2 Products(2)

mRNA Protein Name
NM_001191904.1 NP_001178833.1 homeobox protein Nkx-2.2
NM_001191904.1 NP_001178833.1 homeobox protein Nkx-2.2
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in optic nerve development IEP
IEP: Inferred from expression pattern
15048854 RGD
involved in response to glucose IEP
IEP: Inferred from expression pattern
19134185 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
14568228 RGD
involved in response to progesterone IEP
IEP: Inferred from expression pattern
19053058 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homeobox protein Nkx-2.2

NK2 transcription factor related, locus 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09328 NKX2-2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nkx2-2 NCBI NCBI:4821