2. Gene
  3. Edn3 - endothelin 3 Gene

Edn3 - endothelin 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Et3; RGD1564825; preproET-3

Gene ID: 366270 | Gene type: protein coding

About Edn3

Summary

Predicted to enable endothelin B receptor binding activity and hormone activity. Involved in negative regulation of hormone secretion and regulation of neurotransmitter secretion. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in Hirschsprung's disease; Waardenburg syndrome type 4B; and Waardenburg's syndrome. Orthologous to human EDN3 (endothelin 3). [provided by Alliance of Genome Resources, Apr 2022]

Edn3 Products(1)

mRNA Protein Name
NM_001077650.2 NP_001071118.2 endothelin-3 precursor
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of hormone secretion IDA
IDA: Inferred from direct assay
1533364 RGD
involved in regulation of neurotransmitter secretion IDA
IDA: Inferred from direct assay
12184995 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

endothelin-3

ET-3

PPET3

preproendothelin-3

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04165 EDN3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Edn3 NCBI NCBI:1908