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MAP3K15 - mitogen-activated protein kinase kinase kinase 15 Gene

Also Known as ASK3; bA723P2.3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 389840

About MAP3K15

Cytogenetic location: Xp22.12 Genomic coordinates (GRCh38): X:19,360,059-19,515,508 (from NCBI)

This gene has 4 transcripts (splice variants), 195 orthologues and 2 paralogues. Ubiquitous expression in adrenal (RPKM 7.5), heart (RPKM 3.2) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the mitogen-activated protein kinase (MAPK) family. These family members function in a protein kinase signal transduction cascade, where an activated MAPK kinase kinase (MAP3K) phosphorylates and activates a specific MAPK kinase (MAP2K), which then activates a specific MAPK. This MAP3K protein plays an essential role in apoptotic cell death triggered by cellular stresses. [provided by RefSeq, Jul 2010]

MAP3K15 Products (1)

mRNA	Protein	Name
NM_001001671.4	NP_001001671.3	mitogen-activated protein kinase kinase kinase 15

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables MAP kinase kinase kinase activity	IDA IDA: Inferred from direct assay	26732173	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAP3K15 Protein Structure

DUF4071

Pkinase

0
300
600
900
1200
1313 a.a.

Protein Preferred Names	Protein Names
mitogen-activated protein kinase kinase kinase 15	MAPK/ERK kinase kinase 15

Related Diseases

Diseases	Alias
Neuropathy, Hereditary Sensory And Autonomic, Type Iia	Hereditary Sensory And Autonomic Neuropathy Type 2 Hsan2 HSAN2A Morvan Disease Hereditary Sensory And Autonomic Neuropathy Type Ii Neurogenic Acroosteolysis Hsan Iia Hsn2a Hsn Iia Neuropathy, Progressive Sensory, Of Children Neuropathy, Congenital Sensory Neuropathy, Hereditary Sensory And Autonomic, Type Ii Hereditary Sensory And Autonomic Neuropathy Type 2a Hereditary Sensory And Autonomic Neuropathy Type Iia Hsanii Congenital Sensory Neuropathy Hsan Type Ii Morvan Syndrome Neuropathy, Hereditary Sensory And Autonomic, Type 2a Morvan'S Disease Neuropathy, Hereditary Sensory, Type Iia Acroosteolysis, Neurogenic Acroosteolysis, Giaccai Type Neuropathy, Hereditary Sensory Radicular, Autosomal Recessive Hereditary Sensory Autonomic Neuropathy Type 2 Giaccai Type Acroosteolysis Hereditary Sensory Neuropathy Type 2 Hereditary Sensory Radicular Neuropathy, Recessive Form Hsan2b Hsan2c Hsan2d Hsn Type Ii Autosomal Recessive Sensory Radicular Neuropathy Limbic Encephalitis-Neuromyotonia-Hyperhidrosis-Polyneuropathy Syndrome Morvan Fibrillary Chorea Neuropathy, Hereditary Sensory And Autonomic, 2a Acroosteolysis Giaccai Type Hereditary Sensory Neuropathy Type Iia Hereditary Sensory Radicular Neuropathy Autosomal Recessive Progressive Sensory Neuropathy Of Children Neuropathy Congenital Sensory Charcot-Marie-Tooth Disease Neuropathy, Sensory And Autonomic, Hereditary, Type Iia Hereditary Sensory Autonomic Neuropathy, Type 2 Hereditary Motor And Sensory-Neuropathy Type Ii Sensory Neuropathy, Hereditary Neuropathy, Hereditary Sensory And Autonomic, Type Iib
Martin-Probst Syndrome	Deafness-Intellectual Disability, Martin-Probst Type Syndrome Martin-Probst Deafness-Mental Retardation Syndrome Mental Retardation, X-Linked, Syndromic, Martin-Probst Type MRXSMP Deafness-Intellectual Disability Syndrome, Martin-Probst Type Hearing Loss-Intellectual Disability Syndrome, Martin-Probst Type X-Linked Deafness-Intellectual Disability Syndrome Syndrome X-Linked Hearing Loss-Intellectual Disability Syndrome Syndrome
Large Congenital Melanocytic Nevus	Giant Pigmented Hairy Nevus Giant Congenital Melanocytic Nevus Gmn Congenital Pigmented Nevus Lcmn Gphn Giant Congenital Nevus Bathing Trunk Nevus Congenital Giant Pigmented Nevus Congenital Hairy Nevus Giant Hairy Nevus Giant Pigmented Nevus Congenital Giant Pigmented Nevus Of Skin Congenital Melanocytic Nevus Syndrome Giant Congenital Melanocytic Nevi Giant Congenital Pigmented Nevus Melanocytic Nevus Syndrome, Congenital

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08052	MAP3K15 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MAP3K15	VGNC	VGNC:63377
Mus musculus	MAP3K15	MGD	MGI:2448588
Bos taurus	MAP3K15	VGNC	VGNC:31193
Canis familiaris	MAP3K15	VGNC	VGNC:42971
Rattus norvegicus	MAP3K15	RGD	RGD:1560603
Others	MAP3K15	NCBI