HELT - helt bHLH transcription factor Gene
Also Known as Mgn; HESL; HCM1228; bHLHb44
Species: Homo sapiens
About HELT
This gene has 4 transcripts (splice variants), 204 orthologues and 12 paralogues. Low expression observed in reference dataset.
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anterior/posterior pattern specification; regulation of neurogenesis; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including nervous system development; regulation of transcription by RNA polymerase II; and suckling behavior. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
HELT Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_001300781.2 | NP_001287710.1 | hairy and enhancer of split-related protein HELT isoform 1 |
| NM_001300782.2 | NP_001287711.1 | hairy and enhancer of split-related protein HELT isoform 2 |
HELT Protein Structure
HLH: Helix-loop-helix DNA-binding domain (14 - 65)
Hairy_orange: Hairy Orange (85 - 126)
- 0
- 100
- 200
- 242 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
hairy and enhancer of split-related protein HELT |
|
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Alzheimer Disease 5 |
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| Atypical Autism |
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | HELT | RGD | RGD:1564073 |
| Bos taurus | HELT | VGNC | VGNC:29806 |
| Felis catus | HELT | VGNC | VGNC:62791 |
| Mus musculus | HELT | MGD | MGI:3040955 |
| Macaca mulatta | HELT | VGNC | VGNC:73264 |
| Canis familiaris | HELT | VGNC | VGNC:41651 |
| Others | HELT | NCBI |