MIR100 - microRNA 100 Gene
Also Known as MIRN100; miR-100
Species: Homo sapiens
About MIR100
This gene has 1 transcript (splice variant), 107 orthologues and 7 paralogues.
Summary
MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables mRNA 3'-UTR binding |
IDA
IDA: Inferred from direct assay
|
22684006 | GOA |
| enables mRNA base-pairing translational repressor activity |
IDA
IDA: Inferred from direct assay
|
22684006 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in miRNA-mediated gene silencing by inhibition of translation |
IDA
IDA: Inferred from direct assay
|
27542871 | GOA |
| involved in miRNA-mediated gene silencing by mRNA destabilization |
IDA
IDA: Inferred from direct assay
|
22684006 | GOA |
| acts upstream of negative regulation of BMP signaling pathway |
IMP
IMP: Inferred from mutant phenotype
|
22684006 | GOA |
| acts upstream of negative regulation of gene expression |
IMP
IMP: Inferred from mutant phenotype
|
22684006 | GOA |
| acts upstream of negative regulation of interleukin-8 production |
IDA
IDA: Inferred from direct assay
|
27542871 | GOA |
| acts upstream of negative regulation of osteoblast differentiation |
IMP
IMP: Inferred from mutant phenotype
|
22684006 | GOA |
| involved in negative regulation of vascular associated smooth muscle cell differentiation |
IMP
IMP: Inferred from mutant phenotype
|
18548003 | GOA |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Oral Squamous Cell Carcinoma |
|
|
| Nasopharyngeal Carcinoma |
|
|
| Colorectal Cancer |
|
|
| Ovarian Serous Carcinoma |
|
|
| Endometriosis |
|
|
| Psoriasis |
|
|
| Bladder Cancer |
|
|
| Prostate Cancer |
|
|
| Ovarian Cancer |
|
|
| Pancreatic Cancer |
|
|
| Melanoma |
|
|
| Lung Cancer |
|
|
| Human Papillomavirus Infectious Disease |
|
|
| Vulva Cancer |
|
|
| Cervix Small Cell Carcinoma |
|
|
| Bone Sarcoma |
|
|
| Tongue Carcinoma |
|
|
| Ovary Epithelial Cancer |
|
|
| Female Reproductive System Disease |
|
|
| Tongue Disease |
|
|
| Megalencephalic Leukoencephalopathy With Subcortical Cysts 2b |
|
|
| Reproductive System Disease |
|
|
| Uterine Anomalies |
|
|
| Acute Megakaryocytic Leukemia |
|
|
| Vascular Dementia |
|
|
| Gastrointestinal System Cancer |
|
|
| Bladder Disease |
|
|
| Cervix Disease |
|
|
| Urinary System Disease |
|
|
| Esophageal Disease |
|
|
| Infratentorial Cancer |
|
|
| Gastrointestinal System Disease |
|
|
| Vulvar Disease |
|
|
| Pharynx Cancer |
|
|
| Megalencephalic Leukoencephalopathy With Subcortical Cysts 2a |
|
|
| Male Reproductive System Disease |
|
|
| Head And Neck Cancer |
|
|
| Connective Tissue Cancer |
|
|
| Esophageal Cancer |
|
|
| Malignant Astrocytoma |
|
|
| Respiratory System Disease |
|
|
| Osteoporosis |
|
|
| Connective Tissue Disease |
|
|
| Renal Cell Carcinoma, Nonpapillary |
|
|
| Nervous System Disease |
|
|
| Body Mass Index Quantitative Trait Locus 11 |
|
|
| Type 2 Diabetes Mellitus |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | MIR100 | RGD | RGD:2325389 |
| Mus musculus | MIR100 | MGD | MGI:3619057 |