MIR10B - microRNA 10b Gene
Also Known as MIRN10B; mir-10b; miRNA10B; hsa-mir-10b
Species: Homo sapiens
About MIR10B
This gene has 1 transcript (splice variant), 78 orthologues and 7 paralogues.
Summary
MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables mRNA 3'-UTR binding |
IDA
IDA: Inferred from direct assay
|
19780876 | GOA |
| enables mRNA base-pairing translational repressor activity |
IDA
IDA: Inferred from direct assay
|
19780876 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in miRNA-mediated gene silencing by inhibition of translation |
IDA
IDA: Inferred from direct assay
|
19780876 | GOA |
| involved in miRNA-mediated post-transcriptional gene silencing |
IDA
IDA: Inferred from direct assay
|
22955733 | GOA |
| involved in miRNA-mediated post-transcriptional gene silencing |
IGI
IGI: Inferred from genetic interaction
|
24804980 | GOA |
| involved in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis |
IGI
IGI: Inferred from genetic interaction
|
22955733 | GOA |
| involved in positive regulation of cell migration involved in sprouting angiogenesis |
IGI
IGI: Inferred from genetic interaction
|
22955733 | GOA |
| acts upstream of positive regulation of lipid storage |
IMP
IMP: Inferred from mutant phenotype
|
19780876 | GOA |
| involved in positive regulation of vascular endothelial growth factor receptor signaling pathway |
IGI
IGI: Inferred from genetic interaction
|
22955733 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in extracellular exosome |
IDA
IDA: Inferred from direct assay
|
31926946 | GOA |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Non-Alcoholic Fatty Liver Disease |
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| Bladder Cancer |
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| Breast Cancer |
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| Ovarian Serous Carcinoma |
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| Pancreatitis, Hereditary |
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| Leukemia, Chronic Lymphocytic |
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| Glioblastoma |
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| Pancreatic Cancer |
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| Glioma |
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| Ovarian Cancer |
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| Prostate Cancer |
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| Colorectal Cancer |
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| Esophageal Disease |
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| Thoracic Cancer |
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| Estrogen-Receptor Negative Breast Cancer |
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| Malignant Exocrine Pancreas Neoplasm |
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| Central Nervous System Cancer |
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| Spinal Disease |
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| Connective Tissue Cancer |
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| Endometrial Serous Adenocarcinoma |
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| Endocrine Gland Cancer |
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| Brain Glioma |
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| Malignant Astrocytoma |
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| Endocrine System Disease |
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| Pancreas Disease |
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| Breast Disease |
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| Esophageal Cancer |
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| Gastrointestinal System Cancer |
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| Cervix Small Cell Carcinoma |
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| Bone Cancer |
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| Uterine Corpus Cancer |
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| Pancreatic Ductal Carcinoma |
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| Oral Cavity Cancer |
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| Gastrointestinal System Disease |
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| Nasopharyngeal Carcinoma |
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| Malignant Ovarian Surface Epithelial-Stromal Neoplasm |
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| Stomach Disease |
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| Female Reproductive System Disease |
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| Cell Type Benign Neoplasm |
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| Sporadic Breast Cancer |
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| Head And Neck Cancer |
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| Respiratory System Cancer |
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| Ovary Epithelial Cancer |
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| Colonic Disease |
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| Nasopharyngeal Disease |
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| Reproductive System Disease |
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| Central Nervous System Disease |
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| Large Intestine Cancer |
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| Lung Cancer |
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| Endocrine Organ Benign Neoplasm |
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| Pharynx Cancer |
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| Papillary Adenocarcinoma |
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| Brain Cancer |
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| Pancreatic Ductal Adenocarcinoma |
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| Male Reproductive System Disease |
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| Uterine Anomalies |
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| Respiratory System Disease |
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| Intestinal Disease |
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| Male Reproductive Organ Cancer |
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| Upper Respiratory Tract Disease |
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| Unilateral Focal Polymicrogyria |
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| Prostate Disease |
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| Bladder Disease |
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| High Grade Glioma |
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| Connective Tissue Disease |
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| Hepatocellular Carcinoma |
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| Oral Squamous Cell Carcinoma |
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| Nervous System Disease |
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| Renal Cell Carcinoma, Nonpapillary |
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| Squamous Cell Carcinoma, Head And Neck |
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| Body Mass Index Quantitative Trait Locus 11 |
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | MIR10B | MGD | MGI:2676804 |
| Rattus norvegicus | MIR10B | RGD | RGD:2325397 |