MIR137 - microRNA 137 Gene

Also Known as MIRN137; miR-137

生物種: Homo sapiens

遺伝子タイプ: ncRNA

遺伝子ID: 406928

About MIR137

Cytogenetic location: 1p21.3 Genomic coordinates (GRCh38): 1:98,046,070-98,046,171 (from NCBI)

This gene has 1 transcript (splice variant) and 145 orthologues.

Summary

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	参考文献	由来
enables mRNA 3'-UTR binding	IDA IDA: Inferred from direct assay	23275153	GOA
enables mRNA base-pairing translational repressor activity	IDA IDA: Inferred from direct assay	21067317	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in miRNA-mediated gene silencing by mRNA destabilization	IDA IDA: Inferred from direct assay	23275153	GOA
involved in miRNA-mediated post-transcriptional gene silencing	IDA IDA: Inferred from direct assay	21067317	GOA
involved in negative regulation of G1/S transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	26989074	GOA
involved in negative regulation of angiogenesis	IDA IDA: Inferred from direct assay	24927112	GOA
involved in negative regulation of blood vessel endothelial cell migration	IDA IDA: Inferred from direct assay	24927112	GOA
involved in negative regulation of cell migration	IDA IDA: Inferred from direct assay	26989074	GOA
involved in negative regulation of cell migration	IMP IMP: Inferred from mutant phenotype	23275153	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	26989074	GOA
involved in negative regulation of neuroblast proliferation	IDA IDA: Inferred from direct assay	23400681	GOA
involved in negative regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	30102687	GOA
involved in negative regulation of vascular associated smooth muscle cell migration	IDA IDA: Inferred from direct assay	29016699	GOA
involved in negative regulation of vascular associated smooth muscle cell proliferation	IDA IDA: Inferred from direct assay	29016699	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	26989074	GOA
involved in positive regulation of neuron differentiation	IDA IDA: Inferred from direct assay	23400681	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

関連疾患

Diseases	Alias
Oral Squamous Cell Carcinoma	Mouth Squamous Cell Carcinoma Squamous Cell Carcinoma Of Mouth
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Microphthalmia	Microphthalmos Isolated Anophthalmia-Microphthalmia Syndrome Isolated Microphthalmia-Anophthalmia-Coloboma Simple Microphthalmos Clinical Anophthalmia Isolated Anophthalmia - Microphthalmia Isolated Pure Microphthalmia Mac Spectrum Microphthalmia-Anophthalmia-Coloboma Spectrum Primitive Anophthalmia Globe Of Eye Small Small Eyeball Hypoplasia Of Eye Isolated Nanophthalmos Rudimentary Eye Dysplasia Of Eye
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (12)

製品番号	製品名	純度	Rare Diseases
HY-R00264	hsa-miR-137-3p mimic	99.19%	Unkown
HY-R00264A	hsa-miR-137-3p agomir	99.75%	Unkown
HY-R00265A	hsa-miR-137-5p agomir	99.35%	Unkown
HY-RI00264	hsa-miR-137-3p inhibitor	95.36%	Unkown
HY-RI00264A	hsa-miR-137-3p antagomir	99.68%	Unkown
HY-RI00265A	hsa-miR-137-5p antagomir	99.63%	Unkown
HY-R00265	hsa-miR-137-5p mimic	/	Unkown
HY-R04231	rno-miR-137-5p mimic	/	Unkown
HY-R04231A	rno-miR-137-5p agomir	/	Unkown
HY-RI00265	hsa-miR-137-5p inhibitor	/	Unkown
HY-RI04231	rno-miR-137-5p inhibitor	/	Unkown
HY-RI04231A	rno-miR-137-5p antagomir	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Rattus norvegicus	MIR137	RGD	RGD:2325570
Mus musculus	MIR137	MGD	MGI:2676822