MIR148A - microRNA 148a Gene
Also Known as MIRN148; MIRN148A; mir-148a; hsa-mir-148
Species: Homo sapiens
About MIR148A
This gene has 1 transcript (splice variant), 68 orthologues and 2 paralogues.
Summary
MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables mRNA base-pairing translational repressor activity |
IDA
IDA: Inferred from direct assay
|
18268015 | GOA |
| enables mRNA base-pairing translational repressor activity |
IGI
IGI: Inferred from genetic interaction
|
30451334 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in cholesterol homeostasis |
IDA
IDA: Inferred from direct assay
|
26437365 | GOA |
| involved in miRNA-mediated gene silencing by inhibition of translation |
IDA
IDA: Inferred from direct assay
|
18268015 | GOA |
| involved in miRNA-mediated post-transcriptional gene silencing |
IDA
IDA: Inferred from direct assay
|
20483747 | GOA |
| involved in negative regulation of cholesterol efflux |
IDA
IDA: Inferred from direct assay
|
26437365 | GOA |
| involved in negative regulation of lipoprotein transport |
IDA
IDA: Inferred from direct assay
|
26501192 | GOA |
| involved in negative regulation of low-density lipoprotein particle clearance |
IDA
IDA: Inferred from direct assay
|
26437365 | GOA |
| involved in negative regulation of low-density lipoprotein particle receptor binding |
IDA
IDA: Inferred from direct assay
|
26437365 | GOA |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Esophageal Cancer |
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| Cholangiocarcinoma |
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| Asthma |
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| Miyoshi Muscular Dystrophy 1 |
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| Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 1 |
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| Dermatomyositis |
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| Nemaline Myopathy |
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| Pancreatic Ductal Adenocarcinoma |
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| Muscular Dystrophy, Duchenne Type |
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| Squamous Cell Carcinoma, Head And Neck |
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| Oral Squamous Cell Carcinoma |
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| Pancreatic Cancer |
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| Prostate Cancer |
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| Lung Cancer |
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| Hepatocellular Carcinoma |
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| Larynx Cancer |
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| Breast Cancer |
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| Laryngeal Disease |
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| Lipomatosis, Multiple Symmetric |
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| Upper Respiratory Tract Disease |
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| Mature B-Cell Neoplasm |
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| Chordoma |
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| Endocrine Gland Cancer |
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| Gastrointestinal System Disease |
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| Stomach Disease |
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| Gastrointestinal System Cancer |
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| Nasopharyngeal Carcinoma |
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| Bile Duct Disease |
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| Endocrine System Disease |
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| Biliary Tract Disease |
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| Inherited Metabolic Disorder |
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| Respiratory System Cancer |
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| Nasopharyngeal Disease |
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| Reproductive System Disease |
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| Female Reproductive System Disease |
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| Glucose Metabolism Disease |
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| Respiratory System Disease |
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| Carbohydrate Metabolic Disorder |
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| Lymphatic System Cancer |
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| Pharynx Cancer |
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| Lymphatic System Disease |
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| Overnutrition |
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| Pancreas Disease |
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| Bone Marrow Cancer |
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| Ovary Epithelial Cancer |
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| Acquired Metabolic Disease |
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| Intestinal Disease |
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| Connective Tissue Cancer |
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| Central Nervous System Cancer |
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| Immune System Disease |
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| Thoracic Cancer |
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| Autonomic Nervous System Neoplasm |
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| Male Reproductive Organ Cancer |
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| Male Reproductive System Disease |
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| Lipid Storage Disease |
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| Large Intestine Cancer |
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| Arteries, Anomalies Of |
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| Malignant Astrocytoma |
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| Peripheral Nervous System Neoplasm |
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| Disease By Infectious Agent |
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| Central Nervous System Disease |
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| Colonic Disease |
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| Spinal Disease |
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| Lipid Metabolism Disorder |
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| Hematologic Cancer |
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| Lymphoma, Non-Hodgkin, Familial |
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| Nervous System Disease |
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| Connective Tissue Disease |
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| Renal Cell Carcinoma, Nonpapillary |
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| Body Mass Index Quantitative Trait Locus 11 |
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| Type 2 Diabetes Mellitus |
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| Alzheimer Disease, Familial, 1 |
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | MIR148A | RGD | RGD:9685082 |
| Mus musculus | MIR148A | MGD | MGI:2676833 |