MIR187 - microRNA 187 Gene

Also Known as MIRN187; miR-187; miRNA187

Species: Homo sapiens

Gene Type: ncRNA
Gene ID: 406963

About MIR187

Cytogenetic location: 18q12.2 Genomic coordinates (GRCh38): 18:35,904,818-35,904,926 (from NCBI)

This gene has 1 transcript (splice variant) and 77 orthologues.

Summary

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables mRNA base-pairing translational repressor activity IDA
IDA: Inferred from direct assay
23071313 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to lipopolysaccharide IDA
IDA: Inferred from direct assay
23071313 GOA
involved in miRNA-mediated post-transcriptional gene silencing IDA
IDA: Inferred from direct assay
23071313 GOA
involved in negative regulation of inflammatory response IDA
IDA: Inferred from direct assay
23071313 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Related Diseases

Diseases Alias
Non-Alcoholic Fatty Liver Disease

  • Fatty Liver

  • Non-Alcoholic Fatty Liver

  • Nafld

  • Nonalcoholic Fatty Liver Disease

  • Nonalcoholic Steatohepatitis

  • Steatosis

  • Nafl

  • Nash

  • Non-Alcoholic Steatohepatitis

  • Susceptibility To Nonalcoholic Fatty Liver Disease

  • Steatohepatitis

  • Fatty Degeneration

  • Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis

  • Nafld Without Nash

  • Nafld Without Mention Of Nash
Ampulla Of Vater Adenocarcinoma

  • Adenocarcinoma Of Ampulla Of Vater

  • Ampullary Adenocarcinoma
Juvenile Type Testicular Granulosa Cell Tumor

  • Juvenile Granulosa Cell Tumor

  • Juvenile Granulosa Cell Tumour

  • Juvenile Type Granulosa Cell Neoplasm

  • Juvenile Type Granulosa Cell Tumor

  • Juvenile Type Granulosa Cell Tumour

  • Juvenile Type Testicular Granulosa Cell Tumour
Testicular Granulosa Cell Tumor

  • Granulosa Cell Tumor Of Testis

  • Granulosa Cell Tumour Of Testis

  • Testicular Granulosa Cell Tumour
Thyroid Gland Medullary Carcinoma

  • Medullary Thyroid Carcinoma

  • Medullary Carcinoma Of The Thyroid Gland

  • Ultimobranchial Thyroid Tumor

  • Ultimobranchial Thyroid Tumour

  • Thyroid Cancer, Medullary
Glaucoma, Primary Open Angle

  • Glaucoma 1, Open Angle, E

  • Primary Open Angle Glaucoma

  • POAG

  • Adult-Onset Primary Open Angle Glaucoma

  • Chronic Simple Glaucoma

  • GLC1E

  • Primary Open Angle Glaucoma 1e

  • Glaucoma, Open Angle, Primary
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Respiratory System Disease

  • Abnormality Of The Respiratory System

  • Respiration Disorders

  • Respiratory Tract Diseases
Head And Neck Cancer

  • Head And Neck Neoplasm

  • Head And Neck Tumours

  • Head/Neck Neoplasm

  • Tumor Of Head And Neck

  • Head And Neck Neoplasms

  • Hnc

  • Cancer, Head/Neck
Connective Tissue Disease

  • Connective Tissue Diseases

  • Connective Tissue Disorder

  • Abnormality Of Connective Tissue

  • Disorder Of Connective Tissue

  • Connective Tissue Disorders
Nervous System Disease

  • Abnormality Of The Nervous System

  • Nervous System Diseases

  • Nervous System Disorder
Eye Disease

  • Eye Diseases

  • Abnormality Of The Eye

  • Toxoplasma Oculopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (16)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-R00349 hsa-miR-187-3p mimic / Unkown
HY-R00349A hsa-miR-187-3p agomir / Unkown
HY-R00350 hsa-miR-187-5p mimic / Unkown
HY-R00350A hsa-miR-187-5p agomir / Unkown
HY-R02711 mmu-miR-187-5p mimic / Unkown
HY-R02711A mmu-miR-187-5p agomir / Unkown
HY-R04260 rno-miR-187-5p mimic / Unkown
HY-R04260A rno-miR-187-5p agomir / Unkown
HY-RI00349 hsa-miR-187-3p inhibitor / Unkown
HY-RI00349A hsa-miR-187-3p antagomir / Unkown
HY-RI00350 hsa-miR-187-5p inhibitor / Unkown
HY-RI00350A hsa-miR-187-5p antagomir / Unkown
HY-RI02711 mmu-miR-187-5p inhibitor / Unkown
HY-RI02711A mmu-miR-187-5p antagomir / Unkown
HY-RI04260 rno-miR-187-5p inhibitor / Unkown
HY-RI04260A rno-miR-187-5p antagomir / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MIR187 MGD MGI:2676851
Rattus norvegicus MIR187 RGD RGD:2325557