MIR187 - microRNA 187 Gene

Homo sapiens

Also known as MIRN187; miR-187; miRNA187

Gene ID: 406963 | Gene type: ncRNA

About MIR187

Cytogenetic location: 18q12.2 Genomic coordinates (GRCh38): 18:35,904,818-35,904,926 (from NCBI)

This gene has 1 transcript (splice variant) and 77 orthologues.

Summary

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables mRNA base-pairing translational repressor activity	IDA IDA: Inferred from direct assay	23071313	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to lipopolysaccharide	IDA IDA: Inferred from direct assay	23071313	GOA
involved in miRNA-mediated post-transcriptional gene silencing	IDA IDA: Inferred from direct assay	23071313	GOA
involved in negative regulation of inflammatory response	IDA IDA: Inferred from direct assay	23071313	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Related Diseases

Diseases

Alias

Non-Alcoholic Fatty Liver Disease

Fatty Liver	Non-Alcoholic Fatty Liver
Nafld	Nonalcoholic Fatty Liver Disease
Nonalcoholic Steatohepatitis	Steatosis
Nafl	Nash
Non-Alcoholic Steatohepatitis	Susceptibility To Nonalcoholic Fatty Liver Disease
Steatohepatitis	Fatty Degeneration
Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis	Nafld Without Nash
Nafld Without Mention Of Nash

Ampulla Of Vater Adenocarcinoma

Adenocarcinoma Of Ampulla Of Vater

Ampullary Adenocarcinoma

Juvenile Type Testicular Granulosa Cell Tumor

Juvenile Granulosa Cell Tumor	Juvenile Granulosa Cell Tumour
Juvenile Type Granulosa Cell Neoplasm	Juvenile Type Granulosa Cell Tumor
Juvenile Type Granulosa Cell Tumour	Juvenile Type Testicular Granulosa Cell Tumour

Testicular Granulosa Cell Tumor

Granulosa Cell Tumor Of Testis	Granulosa Cell Tumour Of Testis
Testicular Granulosa Cell Tumour

Thyroid Gland Medullary Carcinoma

Medullary Thyroid Carcinoma	Medullary Carcinoma Of The Thyroid Gland
Ultimobranchial Thyroid Tumor	Ultimobranchial Thyroid Tumour
Thyroid Cancer, Medullary

Glaucoma, Primary Open Angle

Glaucoma 1, Open Angle, E	Primary Open Angle Glaucoma
POAG	Adult-Onset Primary Open Angle Glaucoma
Chronic Simple Glaucoma	GLC1E
Primary Open Angle Glaucoma 1e	Glaucoma, Open Angle, Primary

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Respiratory System Disease

Abnormality Of The Respiratory System	Respiration Disorders
Respiratory Tract Diseases

Head And Neck Cancer

Head And Neck Neoplasm	Head And Neck Tumours
Head/Neck Neoplasm	Tumor Of Head And Neck
Head And Neck Neoplasms	Hnc
Cancer, Head/Neck

Connective Tissue Disease

Connective Tissue Diseases	Connective Tissue Disorder
Abnormality Of Connective Tissue	Disorder Of Connective Tissue
Connective Tissue Disorders

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Eye Disease

Eye Diseases	Abnormality Of The Eye
Toxoplasma Oculopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Purity	Rare Diseases
HY-R00349	hsa-miR-187-3p mimic	/	Unkown
HY-R00349A	hsa-miR-187-3p agomir	/	Unkown
HY-R00350	hsa-miR-187-5p mimic	/	Unkown
HY-R00350A	hsa-miR-187-5p agomir	/	Unkown
HY-R02711	mmu-miR-187-5p mimic	/	Unkown
HY-R02711A	mmu-miR-187-5p agomir	/	Unkown
HY-R04260	rno-miR-187-5p mimic	/	Unkown
HY-R04260A	rno-miR-187-5p agomir	/	Unkown
HY-RI00349	hsa-miR-187-3p inhibitor	/	Unkown
HY-RI00349A	hsa-miR-187-3p antagomir	/	Unkown
HY-RI00350	hsa-miR-187-5p inhibitor	/	Unkown
HY-RI00350A	hsa-miR-187-5p antagomir	/	Unkown
HY-RI02711	mmu-miR-187-5p inhibitor	/	Unkown
HY-RI02711A	mmu-miR-187-5p antagomir	/	Unkown
HY-RI04260	rno-miR-187-5p inhibitor	/	Unkown
HY-RI04260A	rno-miR-187-5p antagomir	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MIR187	MGD	MGI:2676851
Rattus norvegicus	MIR187	RGD	RGD:2325557

Name
Email *

	Sorry, but the email address you supplied was invalid.