MIR200B - microRNA 200b Gene
Also Known as MIRN200B; mir-200b
Species: Homo sapiens
About MIR200B
This gene has 1 transcript (splice variant), 98 orthologues and 2 paralogues.
Summary
MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables mRNA 3'-UTR binding |
IDA
IDA: Inferred from direct assay
|
29778524 | GOA |
| enables mRNA base-pairing translational repressor activity |
IDA
IDA: Inferred from direct assay
|
21081489 | GOA |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Cholangiocarcinoma |
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| Hepatocellular Carcinoma |
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| Ovarian Cancer |
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| Prostate Cancer |
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| Lung Cancer |
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| Breast Cancer |
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| Endometriosis |
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| Ovarian Serous Carcinoma |
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| Non-Alcoholic Fatty Liver Disease |
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| Kidney Cancer |
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| Lung Cancer Susceptibility 3 |
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| Oral Squamous Cell Carcinoma |
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| Melanoma |
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| Chromosomal Deletion Syndrome |
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| Potocki-Shaffer Syndrome |
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| Respiratory System Cancer |
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| Lymphatic System Cancer |
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| Renal Hypertension |
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| Lymphatic System Disease |
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| Chromosomal Disease |
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| Respiratory System Disease |
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| Female Reproductive System Disease |
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| Ovary Epithelial Cancer |
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| Large Cell Neuroendocrine Carcinoma |
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| Marginal Zone B-Cell Lymphoma |
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| Endometrial Adenocarcinoma |
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| Reproductive System Disease |
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| Thoracic Cancer |
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| Endocrine System Disease |
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| Uterine Anomalies |
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| Immune System Disease |
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| Large Cell Carcinoma |
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| Ovarian Disease |
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| Colonic Disease |
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| Male Reproductive Organ Cancer |
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| Lung Large Cell Carcinoma |
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| Malignant Exocrine Pancreas Neoplasm |
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| Intestinal Disease |
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| Male Reproductive System Disease |
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| Large Intestine Cancer |
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| Lymphoma, Mucosa-Associated Lymphoid Type |
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| Leukocyte Disease |
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| Gastrointestinal System Disease |
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| Chromophobe Renal Cell Carcinoma |
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| Head And Neck Cancer |
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| Urinary System Disease |
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| Cervix Disease |
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| Prostate Disease |
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| Cervical Cancer |
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| Esophageal Disease |
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| Breast Disease |
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| Gastrointestinal System Cancer |
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| Pancreas Disease |
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| Central Nervous System Cancer |
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| Connective Tissue Cancer |
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| Hematologic Cancer |
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| Malignant Astrocytoma |
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| Endometrial Cancer |
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| Lung Squamous Cell Carcinoma |
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| Mouth Disease |
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| Endocrine Gland Cancer |
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| Interstitial Lung Disease |
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| Colorectal Cancer |
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| Stomach Disease |
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| Peripheral Nervous System Disease |
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| Spinal Disease |
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| Esophageal Cancer |
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| Central Nervous System Disease |
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| Glucose Metabolism Disease |
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| Carbohydrate Metabolic Disorder |
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| Bone Cancer |
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| Inherited Metabolic Disorder |
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| Lymphoma, Non-Hodgkin, Familial |
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| Cervical Non-Keratinizing Squamous Cell Carcinoma |
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| Bone Marrow Cancer |
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| Purulent Acute Otitis Media |
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| Connective Tissue Disease |
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| Nervous System Disease |
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| Diffuse Large B-Cell Lymphoma |
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| Squamous Cell Carcinoma, Head And Neck |
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| Leukemia, Chronic Lymphocytic |
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| Basal Cell Carcinoma |
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| Skin Disease |
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| Alzheimer Disease, Familial, 1 |
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | MIR200B | RGD | RGD:2325552 |
| Mus musculus | MIR200B | MGD | MGI:2676875 |