MIR212 - microRNA 212 Gene

Also Known as MIRN212; mir-212

Species: Homo sapiens

Gene Type: ncRNA

Gene ID: 406994

About MIR212

Cytogenetic location: 17p13.3 Genomic coordinates (GRCh38): 17:2,050,271-2,050,380 (from NCBI)

This gene has 1 transcript (splice variant), 108 orthologues and 1 paralogue.

Summary

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables mRNA 3'-UTR binding	IDA IDA: Inferred from direct assay	26693054	GOA
enables mRNA base-pairing translational repressor activity	IDA IDA: Inferred from direct assay	22880819	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in miRNA-mediated gene silencing by inhibition of translation	IDA IDA: Inferred from direct assay	22880819	GOA
involved in miRNA-mediated gene silencing by mRNA destabilization	IDA IDA: Inferred from direct assay	26693054	GOA
involved in miRNA-mediated post-transcriptional gene silencing	IDA IDA: Inferred from direct assay	25217442	GOA
involved in negative regulation of angiogenesis	IDA IDA: Inferred from direct assay	25217442	GOA
involved in negative regulation of blood vessel endothelial cell migration	IMP IMP: Inferred from mutant phenotype	25217442	GOA
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	34697900	GOA
involved in negative regulation of cell migration	IMP IMP: Inferred from mutant phenotype	26693054	GOA
acts upstream of negative regulation of gene expression	IDA IDA: Inferred from direct assay	18162065	GOA
involved in negative regulation of gene expression	IDA IDA: Inferred from direct assay	25217442	GOA
involved in negative regulation of inward rectifier potassium channel activity	IDA IDA: Inferred from direct assay	22880819	GOA
involved in negative regulation of nitric oxide biosynthetic process	IDA IDA: Inferred from direct assay	28089352	GOA
involved in negative regulation of peptidyl-cysteine S-nitrosylation	IDA IDA: Inferred from direct assay	28089352	GOA
involved in negative regulation of peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	28089352	GOA
involved in positive regulation of Notch signaling pathway	IDA IDA: Inferred from direct assay	25217442	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	25217442	GOA
involved in transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	25217442	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

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Disease Of Mental Health	Mental Health Mental Disorders
Non-Alcoholic Fatty Liver Disease	Fatty Liver Non-Alcoholic Fatty Liver Nafld Nonalcoholic Fatty Liver Disease Nonalcoholic Steatohepatitis Steatosis Nafl Nash Non-Alcoholic Steatohepatitis Susceptibility To Nonalcoholic Fatty Liver Disease Steatohepatitis Fatty Degeneration Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis Nafld Without Nash Nafld Without Mention Of Nash
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Central Nervous System Disease	Cns Disorder CNS Cns Diseases Central Nervous System Diseases
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Acquired Metabolic Disease
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Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Purity	Rare Diseases
HY-R00442	hsa-miR-212-3p mimic	94.10%	Unkown
HY-R00443	hsa-miR-212-5p mimic	92.87%	Unkown
HY-RI00442	hsa-miR-212-3p inhibitor	93.58%	Unkown
HY-RI00442A	hsa-miR-212-3p antagomir	99.80%	Unkown
HY-RI00443	hsa-miR-212-5p inhibitor	99.47%	Unkown
HY-R00442A	hsa-miR-212-3p agomir	/	Unkown
HY-R00443A	hsa-miR-212-5p agomir	/	Unkown
HY-R02825	mmu-miR-212-3p mimic	/	Unkown
HY-R02825A	mmu-miR-212-3p agomir	/	Unkown
HY-R04302	rno-miR-212-5p mimic	/	Unkown
HY-R04302A	rno-miR-212-5p agomir	/	Unkown
HY-RI00443A	hsa-miR-212-5p antagomir	/	Unkown
HY-RI02825	mmu-miR-212-3p inhibitor	/	Unkown
HY-RI02825A	mmu-miR-212-3p antagomir	/	Unkown
HY-RI04302	rno-miR-212-5p inhibitor	/	Unkown
HY-RI04302A	rno-miR-212-5p antagomir	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MIR212	MGD	MGI:2676888
Rattus norvegicus	MIR212	RGD	RGD:2325376