MIR31 - microRNA 31 Gene
Also Known as MIRN31; miR-31; hsa-mir-31
Species: Homo sapiens
About MIR31
This gene has 1 transcript (splice variant) and 45 orthologues.
Summary
MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables mRNA 3'-UTR binding |
IDA
IDA: Inferred from direct assay
|
22948084 | GOA |
| enables mRNA CDS binding |
IDA
IDA: Inferred from direct assay
|
32069773 | GOA |
| enables mRNA base-pairing translational repressor activity |
IDA
IDA: Inferred from direct assay
|
19949084 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
31012336 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| part of RISC complex |
IGI
IGI: Inferred from genetic interaction
|
31012336 | GOA |
| located in extracellular space |
IDA
IDA: Inferred from direct assay
|
24558106 | GOA |
| located in microvesicle |
IDA
IDA: Inferred from direct assay
|
26933040 | GOA |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Lip And Oral Cavity Cancer |
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| Ovarian Cancer |
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| Breast Cancer |
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| Psoriasis |
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| Squamous Cell Carcinoma, Head And Neck |
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| Oral Squamous Cell Carcinoma |
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| Non-Alcoholic Fatty Liver Disease |
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| Pancreatic Ductal Adenocarcinoma |
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| Bladder Cancer |
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| Melanoma |
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| Lichen Disease |
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| Larynx Cancer |
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| Oral Cavity Cancer |
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| Colorectal Cancer |
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| Prostate Cancer |
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| Lung Cancer |
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| Laryngeal Disease |
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| Large Intestine Cancer |
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| Hepatocellular Carcinoma |
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| Rectal Benign Neoplasm |
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| Lichen Planus |
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| Ossifying Fibroma |
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| Intestinal Disease |
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| Dermatopathia Pigmentosa Reticularis |
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| Intestinal Benign Neoplasm |
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| Colonic Disease |
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| Gastrointestinal System Cancer |
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| Penile Cancer |
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| Colorectal Adenoma |
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| Integumentary System Disease |
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| Head And Neck Cancer |
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| Gastrointestinal System Disease |
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| Respiratory System Cancer |
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| Cleidocranial Dysplasia |
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| Tongue Carcinoma |
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| Upper Respiratory Tract Disease |
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| Gastrointestinal System Benign Neoplasm |
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| Skin Carcinoma |
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| Rectum Cancer |
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| Malignant Exocrine Pancreas Neoplasm |
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| Male Reproductive Organ Cancer |
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| Respiratory System Disease |
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| Thoracic Cancer |
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| Male Reproductive System Disease |
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| Cell Type Benign Neoplasm |
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| Tongue Disease |
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| Bile Duct Cancer |
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| Human Papillomavirus Infectious Disease |
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| Penile Disease |
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| Reproductive System Disease |
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| Chordoma |
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| Bile Duct Adenocarcinoma |
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| Female Reproductive System Disease |
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| Uterine Anomalies |
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| Endocrine System Disease |
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| Cervix Disease |
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| Esophageal Disease |
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| Pancreas Disease |
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| Nasopharyngeal Carcinoma |
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| Endocrine Gland Cancer |
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| Connective Tissue Cancer |
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| Pharynx Cancer |
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| Immune System Disease |
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| Prostate Disease |
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| Bile Duct Disease |
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| Autoimmune Disease Of Gastrointestinal Tract |
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| Stomach Disease |
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| Lymphatic System Cancer |
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| Lymphatic System Disease |
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| Biliary Tract Disease |
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| Colorectal Adenocarcinoma |
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| Breast Disease |
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| Cervical Cancer |
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| Biliary Tract Cancer |
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| Nasopharyngeal Disease |
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| Lynch Syndrome |
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| Autoimmune Disease Of Musculoskeletal System |
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| Large Cell Carcinoma |
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| Peripheral Nervous System Neoplasm |
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| Autonomic Nervous System Neoplasm |
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| Renal Cell Carcinoma, Nonpapillary |
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| Bladder Disease |
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| Mouth Disease |
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| Urinary System Disease |
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| Malignant Astrocytoma |
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| Spinal Disease |
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| Esophageal Cancer |
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| Bone Cancer |
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| Central Nervous System Cancer |
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| Crohn'S Disease |
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| Connective Tissue Disease |
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| Disease By Infectious Agent |
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| Hematologic Cancer |
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| Muscular Dystrophy |
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| Pancreatic Cancer |
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| Skin Disease |
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| Peripheral Nervous System Disease |
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| Lung Cancer Susceptibility 3 |
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| Lymphoma, Non-Hodgkin, Familial |
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| Nervous System Disease |
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| Leukemia, Chronic Lymphocytic |
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| Leukemia, Acute Myeloid |
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| Immune Deficiency Disease |
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | MIR31 | RGD | RGD:2325391 |
| Mus musculus | MIR31 | MGD | MGI:3619330 |