MIR32 - microRNA 32 Gene

Homo sapiens

Also known as MIRN32; miR-32; miRNA32; hsa-mir-32

Gene ID: 407036 | Gene type: ncRNA

About MIR32

Cytogenetic location: 9q31.3 Genomic coordinates (GRCh38): 9:109,046,229-109,046,298 (from NCBI)

This gene has 1 transcript (splice variant) and 78 orthologues.

Summary

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables mRNA base-pairing translational repressor activity	IDA IDA: Inferred from direct assay	18728182	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in miRNA-mediated post-transcriptional gene silencing	IDA IDA: Inferred from direct assay	18728182	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Related Diseases

Diseases

Alias

Myeloma, Multiple

Multiple Myeloma	Plasma Cell Myeloma
Kahler Disease	Myelomatosis
Medullary Plasmacytoma	Multiple Myeloma, Resistance To
Myeloma	Plasma Cell Dyscrasia
Kahler'S Disease	Multiple Myeloma, Susceptibility To
Myeloma - Multiple	Kahler-Bozzolo Disease
Plasma Cell Myelomas	MM
Plasma Cell Neoplasm	Primary Systemic Amyloidosis
Primary Amyloidosis	Immunoglobulin Deposition Disease
Plasmacytic Myeloma	Multiple Myelomata
Multiple Myeloma Nos	Multiple Myeloma Without Mention Of Remission
Monostotic Plasma Cell Myeloma	Mm - [Multiple Myeloma]

Leiomyoma, Uterine

Uterine Leiomyoma	Uterine Fibroid
Uterine Fibroids	Plexiform Leiomyoma
UL	Leiomyoma Of Corpus Uteri
Uterus Fibroma

Breast Large Cell Neuroendocrine Carcinoma

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Pleural Cancer

Pleural Neoplasms	Neoplasm Of Pleura
Pleural Tumor	Malignant Tumor Of Pleura
Pleural Cavity Cancer	Primary Malignant Neoplasm Of Parietal Pleura
Primary Malignant Neoplasm Of Pleura	Primary Malignant Neoplasm Of Visceral Pleura

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Pleural Disease

Pleural Diseases	Disorder Of Pleura
Non-Neoplastic Pleural Disease	Pleural Disorders
Non-Neoplastic Pleural Disorder

Bone Cancer

Malignant Bone Neoplasm	Bone Carcinoma
Bone Neoplasms	Bone Neoplasm
Bone Tumour	Ca - Bone Cancer
Malignant Bone Tumour	Malignant Neoplasm Of Bone
Malignant Osseous Tumor	Neoplasm Of Bone
Osseous Tumor	Osteosarcoma Of Bone
Osteogenic Neoplasm

Contractural Arachnodactyly, Congenital

Congenital Contractural Arachnodactyly	Beals Syndrome
CCA	Beals-Hecht Syndrome
Distal Arthrogryposis Type 9	Arthrogryposis, Distal, Type 9
Da9	Arachnodactyly, Contractural Beals Type
Contractures, Multiple With Arachnodactyly	Ear Anomalies-Contractures-Dysplasia Of Bone With Kyphoscoliosis
Arthrogyroposis, Distal, Type 9	Distal Arthrogyropsis Type 9
Cca Syndrome	Arachnodactyly

Her2-Receptor Positive Breast Cancer

Bronchiolo-Alveolar Adenocarcinoma

Bronchioloalveolar Carcinoma	Bronchioalveolar Lung Carcinoma
Minimally Invasive Lung Adenocarcinoma	Carcinoma Bronchioloalveolar
Adenocarcinoma, Bronchiolo-Alveolar	Bronchioloalveolar Adenocarcinoma

Alveoli Adenoma

Alveolar Adenoma	Adenoma Of Alveoli
Adenoma Of The Alveoli

Mesothelioma, Malignant

Malignant Mesothelioma	Pleural Mesothelioma
MESOM	Mesothelioma, Somatic
Advanced Malignant Mesothelioma	Asbestos-Related Malignant Mesothelioma
Diffuse Malignant Mesothelioma	Malignant Tumor Of Mesothelium
Malignant Mesothelioma, Susceptibility To	Mesothelioma Diffuse Malignant
Mesothelioma	Malignant Pleural Mesothelioma

Connective Tissue Cancer

Neoplasms, Connective Tissue	Connective Tissue Neoplasm
Mesenchymal Tissue Malignant Neoplasm	Neoplasm Of Connective Tissues
Tumour Of Connective Tissue

Suppression Of Tumorigenicity 12

Prostate Adenocarcinoma	Adenocarcinoma Of Prostate
ST12	Prostate Adenocarcinoma 1
Pac1

Male Reproductive Organ Cancer

Genital Neoplasms, Male	Male Genital Cancer
Male Genital Neoplasm	Male Reproductive System Neoplasm
Malignant Neoplasm Of Male Genital Organ	Malignant Neoplasm Of Male Genital Organ Or Tract
Malignant Neoplasm Of Male Genital Organs	Malignant Tumor Of Male Genital Organ
Malignant Tumor Of Male Reproductive System	Neoplasm Of Male Genital Organ
Tumor Of Male Reproductive System

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

Reproductive System Disease

Abnormality Of The Genital System	Genital System Disease
Reproductive System Disorder

Male Reproductive System Disease

Genital Diseases, Male

Disorder Of Male Reproductive System

Respiratory System Disease

Abnormality Of The Respiratory System	Respiration Disorders
Respiratory Tract Diseases

Connective Tissue Disease

Connective Tissue Diseases	Connective Tissue Disorder
Abnormality Of Connective Tissue	Disorder Of Connective Tissue
Connective Tissue Disorders

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Purity	Rare Diseases
HY-R00684	hsa-miR-32-5p mimic	92.34%	Unkown
HY-RI00684	hsa-miR-32-5p inhibitor	93.92%	Unkown
HY-R00680	hsa-miR-32-3p mimic	/	Unkown
HY-R00680A	hsa-miR-32-3p agomir	/	Unkown
HY-R00684A	hsa-miR-32-5p agomir	/	Unkown
HY-R03020	mmu-miR-32-3p mimic	/	Unkown
HY-R03020A	mmu-miR-32-3p agomir	/	Unkown
HY-R04348	rno-miR-32-3p mimic	/	Unkown
HY-R04348A	rno-miR-32-3p agomir	/	Unkown
HY-RI00680	hsa-miR-32-3p inhibitor	/	Unkown
HY-RI00680A	hsa-miR-32-3p antagomir	/	Unkown
HY-RI00684A	hsa-miR-32-5p antagomir	/	Unkown
HY-RI03020	mmu-miR-32-3p inhibitor	/	Unkown
HY-RI03020A	mmu-miR-32-3p antagomir	/	Unkown
HY-RI04348	rno-miR-32-3p inhibitor	/	Unkown
HY-RI04348A	rno-miR-32-3p antagomir	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MIR32	MGD	MGI:3619331
Rattus norvegicus	MIR32	RGD	RGD:2325586

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