MIR98 - microRNA 98 Gene

Also Known as MIRN98; miR-98; MIRLET7L; hsa-mir-98

Species: Homo sapiens

Gene Type: ncRNA

Gene ID: 407054

About MIR98

Cytogenetic location: Xp11.22 Genomic coordinates (GRCh38): X:53,556,223-53,556,341 (from NCBI)

This gene has 1 transcript (splice variant), 62 orthologues and 10 paralogues.

Summary

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables mRNA 3'-UTR binding	IDA IDA: Inferred from direct assay	22492871	GOA
enables mRNA base-pairing translational repressor activity	IDA IDA: Inferred from direct assay	22492871	GOA
enables mRNA base-pairing translational repressor activity	IMP IMP: Inferred from mutant phenotype	28251559	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to amyloid-beta	IMP IMP: Inferred from mutant phenotype	27541017	GOA
involved in miRNA-mediated gene silencing by inhibition of translation	IDA IDA: Inferred from direct assay	27541017	GOA
involved in miRNA-mediated gene silencing by mRNA destabilization	IDA IDA: Inferred from direct assay	27860183	GOA
involved in miRNA-mediated gene silencing by mRNA destabilization	IMP IMP: Inferred from mutant phenotype	28251559	GOA
involved in miRNA-mediated post-transcriptional gene silencing	IDA IDA: Inferred from direct assay	22492871	GOA
acts upstream of negative regulation of BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	27860183	GOA
acts upstream of negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	31886314	GOA
involved in negative regulation of cholesterol biosynthetic process	IDA IDA: Inferred from direct assay	30195495	GOA
involved in negative regulation of cytokine production	IDA IDA: Inferred from direct assay	27860183	GOA
involved in negative regulation of cytokine production involved in inflammatory response	IDA IDA: Inferred from direct assay	31886314	GOA
acts upstream of negative regulation of extracellular matrix assembly	IMP IMP: Inferred from mutant phenotype	28251559	GOA
involved in negative regulation of extracellular matrix disassembly	IDA IDA: Inferred from direct assay	26587789	GOA
acts upstream of negative regulation of gene expression	IDA IDA: Inferred from direct assay	31886314	GOA
acts upstream of negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	27860183	GOA
acts upstream of negative regulation of interleukin-1 beta production	IDA IDA: Inferred from direct assay	31886314	GOA
acts upstream of negative regulation of interleukin-10 production	IDA IDA: Inferred from direct assay	29702181	GOA
involved in negative regulation of interleukin-10 production	IDA IDA: Inferred from direct assay	29702181	GOA
involved in negative regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	31886314	GOA
involved in negative regulation of interleukin-6-mediated signaling pathway	IDA IDA: Inferred from direct assay	26587789	GOA
involved in negative regulation of interleukin-6-mediated signaling pathway	IGI IGI: Inferred from genetic interaction	31886314	GOA
acts upstream of negative regulation of interleukin-8 production	IDA IDA: Inferred from direct assay	31886314	GOA
involved in negative regulation of myofibroblast differentiation	IMP IMP: Inferred from mutant phenotype	28251559	GOA
acts upstream of or within negative regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	27860183	GOA
involved in negative regulation of transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	28251559	GOA
acts upstream of negative regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	31886314	GOA
involved in negative regulation of vascular endothelial cell proliferation	IDA IDA: Inferred from direct assay	26098770	GOA
involved in positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	27541017	GOA
involved in regulation of cytokine production involved in inflammatory response	IDA IDA: Inferred from direct assay	29702181	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Related Diseases

Diseases	Alias
Squamous Cell Carcinoma, Head And Neck	Squamous Cell Carcinoma Of The Head And Neck HNSCC Head And Neck Squamous Cell Carcinoma Squamous Cell Carcinoma Of Lip Squamous Cell Carcinoma, Head And Neck, Somatic Carcinoma Of The Head And Neck Squamous Cell Carcinomas Of Head And Neck Scchn Squamous Cell Carcinoma Of The Hypopharynx Squamous Cell Carcinoma Of The Oropharynx Squamous Cell Carcinoma Of Salivary Glands Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses Squamous Cell Carcinoma Of The Oral Cavity Squamous Cell Carcinoma Of The Lip Carcinoma, Squamous Cell Of Head And Neck Lip Squamous Cell Carcinoma Carcinoma, Squamous Cell, Head And Neck Salivary Gland Squamous Cell Carcinoma Cancer Of Head And Neck Squamous Cell Carcinoma Of Oropharynx Nos
Niemann-Pick Disease, Type C1	Niemann-Pick Disease, Type C NPC1 Niemann-Pick Disease, Type D Niemann-Pick Disease Type C1 Niemann-Pick Disease With Cholesterol Esterification Block Niemann-Pick Disease, Subacute Juvenile Form Neurovisceral Storage Disease With Vertical Supranuclear Ophthalmoplegia Npc Niemann-Pick Disease, Chronic Neuronopathic Form Niemann-Pick Disease Without Sphingomyelinase Deficiency Niemann-Pick Disease Type C Niemann-Pick Disease Type D Niemann-Pick C1 Disease Niemann-Pick Disease C1 Niemann-Pick Disease Chronic Neuronopathic Form Niemann-Pick Disease Nova Scotian Type Niemann-Pick Disease Subacute Juvenile Form Niemann-Pick Disease Type Ii Niemann-Picks Disease Type C
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Hypersensitivity Vasculitis	Cutaneous Small Vessel Vasculitis Hypersensitivity Angiitis Cutaneous Leukocytoclastic Vasculitis Leukocytoclastic Angiitis Vasculitis, Leukocytoclastic, Cutaneous Leukocytoclastic Vasculitis Cutaneous Leukocytoclastic Angiitis Cutaneous Hypersensitivity Vasculitis Vasculitis Hypersensitivity Drug Induced Cutaneous Vasculitis Allergic Vasculitis
Henoch-Schoenlein Purpura	Henoch-Schonlein Purpura Iga Vasculitis Allergic Purpura Anaphylactoid Purpura Rheumatoid Purpura Immunoglobulin A Vasculitis Vascular Purpura Purpura Rheumatica Henoch-Schönlein Purpura Autoimmune Purpura Henoch-Schnlein Purpura Henoch-Sch@Nlein Purpura Henoch-Scholein Purpura Purpura, Autoimmune Henoch Schonlein Purpura Immunoglobulin-A Vasculitis Purpura, Schonlein-Henoch Purpura, Schönlein-Henoch Hsp - Schönlein-Henoch Purpura
Alcohol Use Disorder	Alcohol Abuse Alcoholism Ethanol Abuse Alcohol Addiction Alcohol Dependence Alcoholic Intoxication, Chronic Alcohol-Related Disorders
Respiratory System Disease	Abnormality Of The Respiratory System Respiration Disorders Respiratory Tract Diseases
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Connective Tissue Disease	Connective Tissue Diseases Connective Tissue Disorder Abnormality Of Connective Tissue Disorder Of Connective Tissue Connective Tissue Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RI02543	hsa-miR-98-5p inhibitor	96.95%	Unkown
HY-R02543	hsa-miR-98-5p mimic	99.21%	Unkown
HY-R02540	hsa-miR-98-3p mimic	/	Unkown
HY-R02540A	hsa-miR-98-3p agomir	/	Unkown
HY-R02543A	hsa-miR-98-5p agomir	/	Unkown
HY-R04201	mmu-miR-98-3p mimic	/	Unkown
HY-R04201A	mmu-miR-98-3p agomir	/	Unkown
HY-R04598	rno-miR-98-3p mimic	/	Unkown
HY-R04598A	rno-miR-98-3p agomir	/	Unkown
HY-RI02540	hsa-miR-98-3p inhibitor	/	Unkown
HY-RI02540A	hsa-miR-98-3p antagomir	/	Unkown
HY-RI02543A	hsa-miR-98-5p antagomir	/	Unkown
HY-RI04201	mmu-miR-98-3p inhibitor	/	Unkown
HY-RI04201A	mmu-miR-98-3p antagomir	/	Unkown
HY-RI04598	rno-miR-98-3p inhibitor	/	Unkown
HY-RI04598A	rno-miR-98-3p antagomir	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MIR98	MGD	MGI:3619441
Rattus norvegicus	MIR98	RGD	RGD:2325581