MIR98 - microRNA 98 Gene

Homo sapiens

Also known as MIRN98; miR-98; MIRLET7L; hsa-mir-98

Gene ID: 407054 | Gene type: ncRNA

About MIR98

Cytogenetic location: Xp11.22 Genomic coordinates (GRCh38): X:53,556,223-53,556,341 (from NCBI)

This gene has 1 transcript (splice variant), 62 orthologues and 10 paralogues.

Summary

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables mRNA 3'-UTR binding	IDA IDA: Inferred from direct assay	22492871	GOA
enables mRNA base-pairing translational repressor activity	IDA IDA: Inferred from direct assay	22492871	GOA
enables mRNA base-pairing translational repressor activity	IMP IMP: Inferred from mutant phenotype	28251559	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to amyloid-beta	IMP IMP: Inferred from mutant phenotype	27541017	GOA
involved in miRNA-mediated gene silencing by inhibition of translation	IDA IDA: Inferred from direct assay	27541017	GOA
involved in miRNA-mediated gene silencing by mRNA destabilization	IDA IDA: Inferred from direct assay	27860183	GOA
involved in miRNA-mediated gene silencing by mRNA destabilization	IMP IMP: Inferred from mutant phenotype	28251559	GOA
involved in miRNA-mediated post-transcriptional gene silencing	IDA IDA: Inferred from direct assay	22492871	GOA
acts upstream of negative regulation of BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	27860183	GOA
acts upstream of negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	31886314	GOA
involved in negative regulation of cholesterol biosynthetic process	IDA IDA: Inferred from direct assay	30195495	GOA
involved in negative regulation of cytokine production	IDA IDA: Inferred from direct assay	27860183	GOA
involved in negative regulation of cytokine production involved in inflammatory response	IDA IDA: Inferred from direct assay	31886314	GOA
acts upstream of negative regulation of extracellular matrix assembly	IMP IMP: Inferred from mutant phenotype	28251559	GOA
involved in negative regulation of extracellular matrix disassembly	IDA IDA: Inferred from direct assay	26587789	GOA
acts upstream of negative regulation of gene expression	IDA IDA: Inferred from direct assay	31886314	GOA
acts upstream of negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	27860183	GOA
acts upstream of negative regulation of interleukin-1 beta production	IDA IDA: Inferred from direct assay	31886314	GOA
acts upstream of negative regulation of interleukin-10 production	IDA IDA: Inferred from direct assay	29702181	GOA
involved in negative regulation of interleukin-10 production	IDA IDA: Inferred from direct assay	29702181	GOA
involved in negative regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	31886314	GOA
involved in negative regulation of interleukin-6-mediated signaling pathway	IDA IDA: Inferred from direct assay	26587789	GOA
involved in negative regulation of interleukin-6-mediated signaling pathway	IGI IGI: Inferred from genetic interaction	31886314	GOA
acts upstream of negative regulation of interleukin-8 production	IDA IDA: Inferred from direct assay	31886314	GOA
involved in negative regulation of myofibroblast differentiation	IMP IMP: Inferred from mutant phenotype	28251559	GOA
acts upstream of or within negative regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	27860183	GOA
involved in negative regulation of transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	28251559	GOA
acts upstream of negative regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	31886314	GOA
involved in negative regulation of vascular endothelial cell proliferation	IDA IDA: Inferred from direct assay	26098770	GOA
involved in positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	27541017	GOA
involved in regulation of cytokine production involved in inflammatory response	IDA IDA: Inferred from direct assay	29702181	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Related Diseases

Diseases

Alias

Squamous Cell Carcinoma, Head And Neck

Squamous Cell Carcinoma Of The Head And Neck	HNSCC
Head And Neck Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Lip
Squamous Cell Carcinoma, Head And Neck, Somatic	Carcinoma Of The Head And Neck
Squamous Cell Carcinomas Of Head And Neck	Scchn
Squamous Cell Carcinoma Of The Hypopharynx	Squamous Cell Carcinoma Of The Oropharynx
Squamous Cell Carcinoma Of Salivary Glands	Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses
Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses	Squamous Cell Carcinoma Of The Oral Cavity
Squamous Cell Carcinoma Of The Lip	Carcinoma, Squamous Cell Of Head And Neck
Lip Squamous Cell Carcinoma	Carcinoma, Squamous Cell, Head And Neck
Salivary Gland Squamous Cell Carcinoma	Cancer Of Head And Neck
Squamous Cell Carcinoma Of Oropharynx Nos

Niemann-Pick Disease, Type C1

Niemann-Pick Disease, Type C	NPC1
Niemann-Pick Disease, Type D	Niemann-Pick Disease Type C1
Niemann-Pick Disease With Cholesterol Esterification Block	Niemann-Pick Disease, Subacute Juvenile Form
Neurovisceral Storage Disease With Vertical Supranuclear Ophthalmoplegia	Npc
Niemann-Pick Disease, Chronic Neuronopathic Form	Niemann-Pick Disease Without Sphingomyelinase Deficiency
Niemann-Pick Disease Type C	Niemann-Pick Disease Type D
Niemann-Pick C1 Disease	Niemann-Pick Disease C1
Niemann-Pick Disease Chronic Neuronopathic Form	Niemann-Pick Disease Nova Scotian Type
Niemann-Pick Disease Subacute Juvenile Form	Niemann-Pick Disease Type Ii
Niemann-Picks Disease Type C

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Hypersensitivity Vasculitis

Cutaneous Small Vessel Vasculitis	Hypersensitivity Angiitis
Cutaneous Leukocytoclastic Vasculitis	Leukocytoclastic Angiitis
Vasculitis, Leukocytoclastic, Cutaneous	Leukocytoclastic Vasculitis
Cutaneous Leukocytoclastic Angiitis	Cutaneous Hypersensitivity Vasculitis
Vasculitis Hypersensitivity	Drug Induced Cutaneous Vasculitis
Allergic Vasculitis

Henoch-Schoenlein Purpura

Henoch-Schonlein Purpura	Iga Vasculitis
Allergic Purpura	Anaphylactoid Purpura
Rheumatoid Purpura	Immunoglobulin A Vasculitis
Vascular Purpura	Purpura Rheumatica
Henoch-Schönlein Purpura	Autoimmune Purpura
Henoch-Schnlein Purpura	Henoch-Sch@Nlein Purpura
Henoch-Scholein Purpura	Purpura, Autoimmune
Henoch Schonlein Purpura	Immunoglobulin-A Vasculitis
Purpura, Schonlein-Henoch	Purpura, Schönlein-Henoch
Hsp -	Schönlein-Henoch Purpura

Alcohol Use Disorder

Alcohol Abuse	Alcoholism
Ethanol Abuse	Alcohol Addiction
Alcohol Dependence	Alcoholic Intoxication, Chronic
Alcohol-Related Disorders

Respiratory System Disease

Abnormality Of The Respiratory System	Respiration Disorders
Respiratory Tract Diseases

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Connective Tissue Disease

Connective Tissue Diseases	Connective Tissue Disorder
Abnormality Of Connective Tissue	Disorder Of Connective Tissue
Connective Tissue Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RI02543	hsa-miR-98-5p inhibitor	96.95%	Unkown
HY-R02543	hsa-miR-98-5p mimic	99.21%	Unkown
HY-R02540	hsa-miR-98-3p mimic	/	Unkown
HY-R02540A	hsa-miR-98-3p agomir	/	Unkown
HY-R02543A	hsa-miR-98-5p agomir	/	Unkown
HY-R04201	mmu-miR-98-3p mimic	/	Unkown
HY-R04201A	mmu-miR-98-3p agomir	/	Unkown
HY-R04598	rno-miR-98-3p mimic	/	Unkown
HY-R04598A	rno-miR-98-3p agomir	/	Unkown
HY-RI02540	hsa-miR-98-3p inhibitor	/	Unkown
HY-RI02540A	hsa-miR-98-3p antagomir	/	Unkown
HY-RI02543A	hsa-miR-98-5p antagomir	/	Unkown
HY-RI04201	mmu-miR-98-3p inhibitor	/	Unkown
HY-RI04201A	mmu-miR-98-3p antagomir	/	Unkown
HY-RI04598	rno-miR-98-3p inhibitor	/	Unkown
HY-RI04598A	rno-miR-98-3p antagomir	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MIR98	MGD	MGI:3619441
Rattus norvegicus	MIR98	RGD	RGD:2325581

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