country

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

NDUFC1 - NADH:ubiquinone oxidoreductase subunit C1 Gene

Also Known as KFYI

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4717

About NDUFC1

Cytogenetic location: 4q31.1 Genomic coordinates (GRCh38): 4:139,289,917-139,302,551 (from NCBI)

This gene has 12 transcripts (splice variants) and 120 orthologues. Ubiquitous expression in kidney (RPKM 30.2), heart (RPKM 27.3) and 25 other tissues.

Summary

The encoded protein is a subunit of the NADH:ubiquinone oxidoreductase (complex I), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

NDUFC1 Products (7)

mRNA	Protein	Name
NM_001184986.1	NP_001171915.1	NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial precursor
NM_001184987.1	NP_001171916.1	NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial precursor
NM_001184988.1	NP_001171917.1	NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial precursor
NM_001184989.2	NP_001171918.1	NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial precursor
NM_001184990.1	NP_001171919.1	NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial precursor
NM_001184991.1	NP_001171920.1	NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial precursor
NM_002494.3	NP_002485.1	NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
involved in mitochondrial respiratory chain complex I assembly	IMP IMP: Inferred from mutant phenotype	27626371	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	28844695	GOA
part of respiratory chain complex I	IDA IDA: Inferred from direct assay	27626371	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NDUFC1 Protein Structure

NADH_dh_m_C1

0
76 a.a.

Protein Preferred Names	Protein Names
NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial	CI-KFYI

Related Diseases

Diseases	Alias
Bacterial Gastritis
Mitochondrial Dna Depletion Syndrome 9	MTDPS9 Fatal Infantile Lactic Acidosis Lactic Acidosis, Fatal Infantile, Formerly Fatal Infantile Lactic Acidosis With Methylmalonic Aciduria Mitochondrial Dna Depletion Syndrome 9 Encephalomyopathic Type With Methylmalonic Aciduria Mitochondrial Dna Depletion Syndrome, Type 9 Lactic Acidosis, Fatal Infantile
Plethora Of Newborn	Neonatal Polycythemia
Leber Optic Atrophy And Dystonia	LDYT Marsden Syndrome Leber Hereditary Optic Neuropathy With Dystonia Leber Hereditary Optic Neuropathy And Dystonia Familial Dystonia With Visual Failure And Striatal Lucencies Dystonia, Familial, With Visual Failure And Striatal Lucencies Leber Optic Atrophy With Dystonia Dystonia Familial, With Visual Failure And Striatal Lucencies Lhon And Dystonia Leber'S Hereditary Optic Neuropathy With Dystonia
Leigh Syndrome	Leigh Disease Infantile Subacute Necrotizing Encephalopathy Leigh Syndrome Due To Mitochondrial Complex Iv Deficiency LS Sne Leigh'S Disease Leigh Syndrome Due To Mitochondrial Complex I Deficiency Necrotizing Encephalopathy, Infantile Subacute, Of Leigh Subacute Necrotizing Encephalomyelopathy Necrotizing Encephalopathy Infantile Subacute Of Leigh Leigh Syndrome Due To Mitochondrial Complex Iii Deficiency Infantile Necrotizing Encephalomyelopathy Juvenile Subacute Necrotizing Encephalomyelopathy Leigh'S Necrotizing Encephalopathy Subacute Necrotizing Encephalopathy Juvenile Subacute Necrotizing Encephalopathy Leigh Syndrome Due To Mitochondrial Complex Ii Deficiency Leigh Syndrome Due To Mitochondrial Complex V Deficiency Encephalopathy, Subacute Necrotizing, Infantile Encephalopathy, Subacute Necrotizing, Juvenile Maternally Inherited Leigh Syndrome Subacute Necrotising Encephalomyelopathy Subacute Necrotising Encephalopathy
Mitochondrial Complex I Deficiency, Nuclear Type 1	Mitochondrial Complex I Deficiency Nadh:Q(1) Oxidoreductase Deficiency MC1DN1 Nadh-Coenzyme Q Reductase Deficiency Isolated Mitochondrial Respiratory Chain Complex I Deficiency Isolated Nadh-Coenzyme Q Reductase Deficiency Isolated Nadh-Coq Reductase Deficiency Isolated Nadh-Ubiquinone Reductase Deficiency Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of Nuclear Type Mitochondrial Complex I Deficiency 1 Isolated Complex I Deficiency Complex 1 Mitochondrial Respiratory Chain Deficiency Nadh Coenzyme Q Reductase Deficiency Complex I Mitochondrial Respiratory Chain Deficiency Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I Nadh:Ubiquinone Oxidoreductase Deficiency Complex I, Mitochondrial Respiratory Chain, Deficiency Of

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09155	NDUFC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21896	Ndufc1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28413	Ndufc1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NDUFC1	MGD	MGI:1913627
Rattus norvegicus	NDUFC1	RGD	RGD:1586362
Bos taurus	NDUFC1	VGNC	VGNC:31968
Others	NDUFC1	NCBI