NPAS1 - neuronal PAS domain protein 1 Gene
Also Known as MOP5; PASD5; bHLHe11
Species: Homo sapiens
About NPAS1
This gene has 8 transcripts (splice variants), 180 orthologues and 7 paralogues. Biased expression in brain (RPKM 1.1), stomach (RPKM 0.8) and 8 other tissues.
Summary
The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. Studies of a related mouse gene suggest that it functions in neurons. The exact function of this gene is unclear, but it may play protective or modulatory roles during late embryogenesis and postnatal development. [provided by RefSeq, Jul 2008]
NPAS1 Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_001321086.2 | NP_001308015.1 | neuronal PAS domain-containing protein 1 isoform 2 |
| NM_002517.4 | NP_002508.2 | neuronal PAS domain-containing protein 1 isoform 1 |
NPAS1 Protein Structure
HLH: Helix-loop-helix DNA-binding domain (52 - 96)
PAS: PAS fold (141 - 198)
PAS_3: PAS fold (316 - 388)
- 0
- 100
- 200
- 300
- 400
- 500
- 590 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
neuronal PAS domain-containing protein 1 |
|
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Noonan Syndrome 1 |
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Felis catus | NPAS1 | VGNC | VGNC:68525 |
| Macaca mulatta | NPAS1 | VGNC | VGNC:75377 |
| Rattus norvegicus | NPAS1 | RGD | RGD:1310040 |
| Mus musculus | NPAS1 | MGD | MGI:109205 |
| Bos taurus | NPAS1 | VGNC | VGNC:32189 |
| Canis familiaris | NPAS1 | VGNC | VGNC:43908 |
| Others | NPAS1 | NCBI |