NRAP - nebulin related anchoring protein Gene

Also Known as N-RAP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4892

About NRAP

Cytogenetic location: 10q25.3 Genomic coordinates (GRCh38): 10:113,588,714-113,664,041 (from NCBI)

This gene has 4 transcripts (splice variants), 202 orthologues and 4 paralogues. Biased expression in heart (RPKM 131.4), prostate (RPKM 26.5) and 2 other tissues.

Summary

Predicted to enable actin filament binding activity and muscle alpha-actinin binding activity. Predicted to be involved in cardiac muscle thin filament assembly. Predicted to be located in fascia adherens; muscle tendon junction; and myofibril. Predicted to be active in Z disc. [provided by Alliance of Genome Resources, Apr 2022]

NRAP Products (4)

mRNA Protein Name
NM_001261463.2 NP_001248392.1 nebulin-related-anchoring protein isoform 3
NM_001322945.2 NP_001309874.1 nebulin-related-anchoring protein isoform 4
NM_006175.5 NP_006166.3 nebulin-related-anchoring protein isoform 1
NM_198060.4 NP_932326.2 nebulin-related-anchoring protein isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15205937 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NRAP Protein Structure

LIM

LIM: LIM domain (6 - 57)

Nebulin

Nebulin: Nebulin repeat (175 - 199)

Nebulin

Nebulin: Nebulin repeat (209 - 237)

Nebulin

Nebulin: Nebulin repeat (316 - 343)

Nebulin

Nebulin: Nebulin repeat (493 - 520)

Nebulin

Nebulin: Nebulin repeat (529 - 556)

Nebulin

Nebulin: Nebulin repeat (564 - 592)

Nebulin

Nebulin: Nebulin repeat (732 - 759)

Nebulin

Nebulin: Nebulin repeat (767 - 795)

Nebulin

Nebulin: Nebulin repeat (804 - 831)

Nebulin

Nebulin: Nebulin repeat (844 - 869)

Nebulin

Nebulin: Nebulin repeat (975 - 1003)

Nebulin

Nebulin: Nebulin repeat (1046 - 1074)

Nebulin

Nebulin: Nebulin repeat (1084 - 1112)

Nebulin

Nebulin: Nebulin repeat (1218 - 1245)

Nebulin

Nebulin: Nebulin repeat (1255 - 1280)

Nebulin

Nebulin: Nebulin repeat (1362 - 1388)

Nebulin

Nebulin: Nebulin repeat (1496 - 1524)

Nebulin

Nebulin: Nebulin repeat (1570 - 1597)

Nebulin

Nebulin: Nebulin repeat (1640 - 1664)

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  • 1730 a.a.
Protein Preferred Names Protein Names

nebulin-related-anchoring protein

Related Diseases

Diseases Alias
Myopathy, Myofibrillar, 5

  • Myofibrillar Myopathy 5

  • MFM5

  • Myopathy, Myofibrillar, Filamin C-Related

  • Filaminopathy, Autosomal Dominant

  • Filaminopathy

  • Muscle Filaminopathy

  • Autosomal Dominant Filaminopathy

  • Mfm Filamin C-Related

  • Myopathy Myofibrillar Filamin C-Related

  • Myopathy, Myofibrillar, Type 5
Myopathy, Myofibrillar, 4

  • Myofibrillar Myopathy 4

  • MFM4

  • Zaspopathy

  • Myopathy, Myofibrillar, Zasp-Related
Myopathy, Myofibrillar, 9, With Early Respiratory Failure

  • Hereditary Myopathy With Early Respiratory Failure

  • Hmerf

  • Myopathy, Proximal, With Early Respiratory Muscle Involvement

  • Edstrom Myopathy

  • Mfm-Titinopathy

  • MFM9

  • Mprm

  • Hereditary Inclusion Body Myopathy With Early Respiratory Failure

  • Hibm-Erf

  • Myofibrillar Myopathy-Titinopathy

  • Myofibrillar Myopathy With Early Respiratory Failure

  • Myopathy, Distal, With Early Respiratory Failure, Autosomal Dominant

  • Myofibrillar Myopathy 9

  • Myofibrillar Myopathy 9 With Early Respiratory Failure

  • Autosomal Dominant Distal Myopathy With Early Respiratory Failure

  • Proximal Myopathy With Early Respiratory Muscle Involvement

  • Hereditary Proximal Myopathy With Early Respiratory Failure

  • Admerf

  • Edström Myopathy

  • Hmerf-Erf
Myofibrillar Myopathy

  • Desmin Related Myopathy

  • Myotilinopathy

  • Myopathy, Myofibrillar

  • Alpha Beta Crystallinopathy

  • Desmin Storage Myopathy

  • Desminopathy

  • Filaminopathy

  • Protein Surplus Myopathy

  • Zaspopathy

  • Myofibrillar Myopathies

  • Myopathy, Myofibrillar, Desmin-Related

  • Myopathy, Desmin Storage

  • Mfm - [Myofibrillar Myopathy]
Dilated Cardiomyopathy

  • Familial Dilated Cardiomyopathy

  • Primary Dilated Cardiomyopathy

  • Idiopathic Dilated Cardiomyopathy

  • Congestive Cardiomyopathy

  • Idiopathic Dilation Cardiomyopathy

  • Primary Familial Dilated Cardiomyopathy

  • Cardiomyopathy, Dilated

  • DCM

  • Cardiomyopathy, Familial Dilated

  • Dilated Cardiomyopathy, Familial

  • Hypokinetic Dilated Cardiomyopathy, Familial

  • Familial Idiopathic Cardiomyopathy

  • Fdc

  • Cardiomyopathy, Familial Idiopathic

  • Idiopathic Cardiomegaly

  • Dilated Congestive Cardiomyopathy

  • Chronic Dilated Cardiomyopathy

  • Ccm - [Congestive Cardiomyopathy]

  • Cocm - [Congestive Cardiomyopathy]

  • Dcm - [Dilated Cardiomyopathy]

  • Dilated-Hypokinetic Cardiomyopathy

  • Congestive Idiopathic Cardiomyopathy

  • Primary Idiopathic Dilated Cardiomyopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09416 NOL6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09556 NRAP Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NRAP RGD RGD:1306731
Felis catus NRAP VGNC VGNC:68559
Macaca mulatta NRAP VGNC VGNC:75523
Bos taurus NRAP VGNC VGNC:32251
Canis familiaris NRAP VGNC VGNC:43957
Mus musculus NRAP MGD MGI:1098765
Others NRAP NCBI