Gjc2 - gap junction protein, gamma 2 Gene

Also Known as Cx47; Gja12

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 497913

Summary

Predicted to enable gap junction channel activity involved in cell communication by electrical coupling. Involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle; nervous system development; and positive regulation of calcium ion transmembrane transport. Located in several cellular components, including paranode region of axon; perikaryon; and proximal neuron projection. Biomarker of Parkinson's disease. Human ortholog(s) of this gene implicated in hereditary lymphedema IC; hereditary spastic paraplegia 44; hypomyelinating leukodystrophy 2; and lymphedema. Orthologous to human GJC2 (Gap Junction Protein gamma 2). [provided by Alliance of Genome Resources, Apr 2022]

Gjc2 Products (1)

mRNA Protein Name
NM_001100784.1 NP_001094254.1 gap junction gamma-2 protein

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in negative regulation of G1/S transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
28278052 RGD
involved in positive regulation of calcium ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
28278052 RGD
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
28278052 RGD
involved in positive regulation of oligodendrocyte progenitor proliferation IMP
IMP: Inferred from mutant phenotype
28278052 RGD
involved in regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
28278052 RGD
Cellular Component GO Annotation Evidence References Source
located in gap junction IDA
IDA: Inferred from direct assay
16203097 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
16203097 RGD
located in paranode region of axon IDA
IDA: Inferred from direct assay
16203097 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
15293232 RGD
located in proximal neuron projection IDA
IDA: Inferred from direct assay
15293232 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

gap junction gamma-2 protein

  • connexin-47

  • gap junction alpha-12 protein

  • gap junction membrane channel protein alpha 12

  • gap junction protein, alpha 12

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05453 GJC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gjc2 NCBI NCBI:57165