SYNE1 - Syne1 spectrin repeat containing nuclear envelope protein 1 Gene

Also Known as CPG2; Myne-1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 499010

Summary

Enables enzyme binding activity and signaling receptor binding activity. Involved in several processes, including negative regulation of mesenchymal cell apoptotic process; negative regulation of mini excitatory postsynaptic potential; and regulation of receptor-mediated endocytosis. Located in several cellular components, including dendritic spine head; midbody; and nuclear membrane. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita (multiple); bipolar disorder; cerebellar ataxia (multiple); and muscular dystrophy (multiple). Orthologous to human SYNE1 (spectrin repeat containing nuclear envelope protein 1). [provided by Alliance of Genome Resources, Apr 2022]

SYNE1 Products (24)

mRNA Protein Name
XM_039101511.1 XP_038957439.1 nesprin-1 isoform X23
XM_039101500.1 XP_038957428.1 nesprin-1 isoform X8
XM_039101506.1 XP_038957434.1 nesprin-1 isoform X14
XM_039101507.1 XP_038957435.1 nesprin-1 isoform X15
XM_039101510.1 XP_038957438.1 nesprin-1 isoform X17
XM_039101504.1 XP_038957432.1 nesprin-1 isoform X12
XM_039101496.1 XP_038957424.1 nesprin-1 isoform X4
XM_039101495.1 XP_038957423.1 nesprin-1 isoform X3
XM_039101494.1 XP_038957422.1 nesprin-1 isoform X2
XM_039101505.1 XP_038957433.1 nesprin-1 isoform X13
XM_039101502.1 XP_038957430.1 nesprin-1 isoform X10
XM_039101493.1 XP_038957421.1 nesprin-1 isoform X1
XM_039101497.1 XP_038957425.1 nesprin-1 isoform X5
XM_008758713.3 XP_008756935.2 nesprin-1 isoform X19
XM_006227851.4 XP_006227913.1 nesprin-1 isoform X20
XM_006227852.4 XP_006227914.1 nesprin-1 isoform X22
XM_039101499.1 XP_038957427.1 nesprin-1 isoform X7
XM_039101492.1 XP_038957420.1 nesprin-1 isoform X1
XM_039101503.1 XP_038957431.1 nesprin-1 isoform X11
XM_039101501.1 XP_038957429.1 nesprin-1 isoform X9
XM_039101498.1 XP_038957426.1 nesprin-1 isoform X6
XM_017590500.2 XP_017445989.2 nesprin-1 isoform X18
XM_039101509.1 XP_038957437.1 nesprin-1 isoform X16
XM_006227853.4 XP_006227915.1 nesprin-1 isoform X21

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables enzyme binding IDA
IDA: Inferred from direct assay
15652351 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15652351 RGD
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
15652351 RGD
Biological Process GO Annotation Evidence References Source
involved in cardiac muscle cell differentiation IEP
IEP: Inferred from expression pattern
25339194 RGD
involved in negative regulation of mesenchymal cell apoptotic process IMP
IMP: Inferred from mutant phenotype
23863972 RGD
involved in negative regulation of mini excitatory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
24191017 RGD
involved in positive regulation of mesenchymal cell proliferation IMP
IMP: Inferred from mutant phenotype
23863972 RGD
involved in positive regulation of receptor-mediated endocytosis IMP
IMP: Inferred from mutant phenotype
15541315 RGD
involved in regulation of dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
15541315 RGD
involved in regulation of nucleus organization IMP
IMP: Inferred from mutant phenotype
23863972 RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization IDA
IDA: Inferred from direct assay
15541315 RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization IEP
IEP: Inferred from expression pattern
15541315 RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization IMP
IMP: Inferred from mutant phenotype
15541315 RGD
involved in response to light stimulus IEP
IEP: Inferred from expression pattern
8700883 RGD
Cellular Component GO Annotation Evidence References Source
located in dendritic spine IDA
IDA: Inferred from direct assay
15541315 RGD
located in dendritic spine head IDA
IDA: Inferred from direct assay
24191017 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
15541315 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
15541315 RGD
located in midbody IDA
IDA: Inferred from direct assay
14709720 RGD
located in nuclear envelope IDA
IDA: Inferred from direct assay
11792814 RGD
located in nuclear membrane IDA
IDA: Inferred from direct assay
23863972 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
15652351 RGD
is active in postsynaptic actin cytoskeleton IDA
IDA: Inferred from direct assay
24191017 RGD
is active in postsynaptic actin cytoskeleton IMP
IMP: Inferred from mutant phenotype
24191017 RGD
is active in postsynaptic endocytic zone IDA
IDA: Inferred from direct assay
15541315 RGD
is active in postsynaptic endocytic zone IMP
IMP: Inferred from mutant phenotype
35072626 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nesprin-1

  • nesprin-1-like

  • spectrin repeat containing, nuclear envelope 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14085 SYNE1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22841 Syne1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens SYNE1 NCBI NCBI:23345