Wdr35 - WD repeat domain 35 Gene

Also Known as RGD1564116

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 503018

Summary

Involved in several processes, including cellular response to paclitaxel; liver regeneration; and negative regulation of nitric oxide biosynthetic process. Located in cytoplasm. Biomarker of liver cirrhosis. Human ortholog(s) of this gene implicated in Ellis-Van Creveld syndrome; cranioectodermal dysplasia 2; and short-rib thoracic dysplasia 7 with or without polydactyly. Orthologous to human WDR35 (WD repeat domain 35). [provided by Alliance of Genome Resources, Apr 2022]

Wdr35 Products (1)

mRNA Protein Name
NM_001099340.1 NP_001092810.1 WD repeat-containing protein 35

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
20224876 RGD
involved in cellular response to tumor necrosis factor IMP
IMP: Inferred from mutant phenotype
20193664 RGD
involved in cellular response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
18472094 RGD
involved in liver regeneration IEP
IEP: Inferred from expression pattern
18472094 RGD
involved in negative regulation of gene expression IDA
IDA: Inferred from direct assay
18671723 RGD
involved in negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
23289926 RGD
involved in negative regulation of nitric oxide biosynthetic process IDA
IDA: Inferred from direct assay
18671723 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
20193664 RGD
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
20193664 RGD
involved in positive regulation of release of cytochrome c from mitochondria IMP
IMP: Inferred from mutant phenotype
23289926 RGD
involved in positive regulation of vasoconstriction IDA
IDA: Inferred from direct assay
18671723 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
24803807 RGD
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
23289926 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

WD repeat-containing protein 35

  • naofen

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15774 WDR35 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Wdr35 NCBI NCBI:57539