Wdr35 - WD repeat domain 35 Gene

Rattus norvegicus

Also known as RGD1564116

Gene ID: 503018 | Gene type: protein coding

About Wdr35

Summary

Involved in several processes, including cellular response to paclitaxel; liver regeneration; and negative regulation of nitric oxide biosynthetic process. Located in cytoplasm. Biomarker of liver cirrhosis. Human ortholog(s) of this gene implicated in Ellis-Van Creveld syndrome; cranioectodermal dysplasia 2; and short-rib thoracic dysplasia 7 with or without polydactyly. Orthologous to human WDR35 (WD repeat domain 35). [provided by Alliance of Genome Resources, Apr 2022]

Wdr35 Products(1)

mRNA	Protein	Name
NM_001099340.1	NP_001092810.1	WD repeat-containing protein 35

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to glucose stimulus	IEP IEP: Inferred from expression pattern	20224876	RGD
involved in cellular response to tumor necrosis factor	IMP IMP: Inferred from mutant phenotype	20193664	RGD
involved in cellular response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	18472094	RGD
involved in liver regeneration	IEP IEP: Inferred from expression pattern	18472094	RGD
involved in negative regulation of gene expression	IDA IDA: Inferred from direct assay	18671723	RGD
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23289926	RGD
involved in negative regulation of nitric oxide biosynthetic process	IDA IDA: Inferred from direct assay	18671723	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	20193664	RGD
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	20193664	RGD
involved in positive regulation of release of cytochrome c from mitochondria	IMP IMP: Inferred from mutant phenotype	23289926	RGD
involved in positive regulation of vasoconstriction	IDA IDA: Inferred from direct assay	18671723	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	24803807	RGD
involved in response to toxic substance	IEP IEP: Inferred from expression pattern	23289926	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

WD repeat-containing protein 35

naofen

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15774	WDR35 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Wdr35	NCBI	NCBI:57539

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