Gja5 - gap junction protein, alpha 5 Gene

Also Known as Cx40; Cxni

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 50563

Summary

Enables connexin binding activity; disordered domain specific binding activity; and gap junction channel activity. Involved in several processes, including blood vessel diameter maintenance; cell communication by chemical coupling; and regulation of blood pressure. Located in cell projection. Part of connexin complex. Used to study hypertension. Biomarker of artery disease (multiple); glomerulonephritis; obesity; and ureteral obstruction. Human ortholog(s) of this gene implicated in atrial fibrillation; atrial standstill 1; familial atrial fibrillation; and tetralogy of Fallot. Orthologous to human GJA5 (Gap Junction Protein alpha 5). [provided by Alliance of Genome Resources, Apr 2022]

Gja5 Products (1)

mRNA	Protein	Name
NM_019280.1	NP_062153.1	gap junction alpha-5 protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables connexin binding	IPI IPI: Inferred from physical interaction	11557558	RGD
enables disordered domain specific binding	IPI IPI: Inferred from physical interaction	19808665	RGD
enables gap junction channel activity	IDA IDA: Inferred from direct assay	1328644	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cell communication by chemical coupling	IDA IDA: Inferred from direct assay	1328644	RGD
involved in cell communication by electrical coupling	IDA IDA: Inferred from direct assay	7554128	RGD
involved in endothelium development	IEP IEP: Inferred from expression pattern	10990491	RGD
involved in heart development	IEP IEP: Inferred from expression pattern	8944820	RGD
involved in negative regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	18046320	RGD
involved in negative regulation of glomerular filtration	IMP IMP: Inferred from mutant phenotype	17928514	RGD
involved in positive regulation of cell communication by chemical coupling	IMP IMP: Inferred from mutant phenotype	15678088	RGD
involved in positive regulation of vasoconstriction	IMP IMP: Inferred from mutant phenotype	21414209	RGD
involved in potassium ion transport	IDA IDA: Inferred from direct assay	7554128	RGD
involved in regulation of cell communication by electrical coupling	IDA IDA: Inferred from direct assay	11557558	RGD
involved in vasodilation	IMP IMP: Inferred from mutant phenotype	16037574	RGD
involved in vasomotion	IMP IMP: Inferred from mutant phenotype	16815985	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in cell projection	IDA IDA: Inferred from direct assay	16037574	RGD
part of connexin complex	IDA IDA: Inferred from direct assay	1328644	RGD
part of connexin complex	IMP IMP: Inferred from mutant phenotype	19808665	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
gap junction alpha-5 protein	connexin 40 connexin i gap junction membrane channel protein alpha 5

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05444	GJA5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gja5	NCBI	NCBI:2702