PCA3 - prostate cancer associated 3 Gene

Also Known as DD3; PCAT3; NCRNA00019; PRUNE2-AS1

Species: Homo sapiens

Gene Type: ncRNA
Gene ID: 50652

About PCA3

Cytogenetic location: 9q21.2 Genomic coordinates (GRCh38): 9:76,764,436-76,787,569 (from NCBI)

This gene has 18 transcripts (splice variants). Restricted expression toward prostate (RPKM 4.9).

Summary

This gene produces a spliced, long non-coding RNA that is highly overexpressed in most types of prostate Cancer cells and is used as a specific biomarker for this type of Cancer. This gene is embedded in an intronic region of the prune2 gene on the opposite DNA strand. The transcript regulates prune2 levels through formation of a double-stranded RNA that undergoes Adenosine Deaminase acting on RNA-dependent adenosine-to-inosine RNA editing. In prostate Cancer derived cells, overexpression of PCA induced downregulation of prune2, leading to decreased cell proliferation. Conversely, silencing in prostate Cancer cells resulted in increased proliferation. Regulation of this gene appears to be sensitive to androgen-receptor activation, a molecular signature of prostate Cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2017]

Related Diseases

Diseases Alias
Prostate Disease

  • Prostatic Diseases

  • Prostate Diseases
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Parkinson Disease, Late-Onset

  • Parkinson Disease

  • Parkinson'S Disease

  • PD

  • PARK

  • Parkinson Disease, Susceptibility To

  • Late Onset Parkinson'S Disease

  • Late Onset Parkinson Disease

  • Paralysis Agitans

  • Primary Parkinsonism

  • Idiopathic Parkinson Disease

  • Parkinson'S

  • Parkinson Disease, Late-Onset, Susceptibility To

  • Parkinson Disease, Age Of Onset, Modifier

  • Lewy Body Parkinson Disease

  • Idiopathic Parkinson'S Disease

  • Pd - [Parkinson Disease]

  • Parkinson Disease Nos

  • Parkinson, Nos

  • Primary Parkinson Disease
Prostatitis
Prostatic Hyperplasia, Benign

  • Benign Prostatic Hyperplasia

  • BPH

  • Prostatic Hyperplasia
Prostatic Hypertrophy

  • Benign Prostatic Hypertrophy

  • Prostatic Hyperplasia
Primary Cutaneous Amyloidosis

  • Plca

  • Primary Localized Cutaneous Amyloidosis

  • Familial Primary Localized Cutaneous Amyloidosis

  • Amyloidosis Ix

  • Lichen Amyloidosis Familial

  • Amyloidosis, Primary Cutaneous

  • Pca

  • Amyloidosis 9

  • Amyloidosis Familial Cutaneous Lichen

  • Fplca

  • Familial Lichen Amyloidosis
Prostate Stromal Sarcoma

  • Stromal Sarcoma Of The Prostate
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma