H1f2 - H1.2 linker histone, cluster member Gene

Also Known as H1c; H1-2; H1.2; His1a; H1var1; Hist1h1c; 0610008C09Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 50708

Summary

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Feb 2014]

H1f2 Products (2)

mRNA Protein Name
NM_015786.3 NP_056601.1 histone H1.2
NM_015786.3 NP_056601.1 histone H1.2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
15562002 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10893414 MGI
enables structural constituent of chromatin IMP
IMP: Inferred from mutant phenotype
12808097 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within chromatin organization IMP
IMP: Inferred from mutant phenotype
12808097 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
22083958 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
22701719 MGI
Cellular Component GO Annotation Evidence References Source
located in euchromatin IDA
IDA: Inferred from direct assay
22083958 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

histone H1.2

  • H1 VAR.1

  • H1 histone family, member 2

  • histone 1, H1c

  • histone H1

  • histone cluster 1, H1c

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05947 H1-2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown