2. Gene
  3. Rgs6 - regulator of G-protein signaling 6 Gene

Rgs6 - regulator of G-protein signaling 6 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 50779 | Gene type: protein coding

About Rgs6

Summary

This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP (Dishevelled, Egl-10, and Pleckstrin) and GGL (G-protein gamma like)domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and Cancer risk. Mice lacking this gene exhibit decreased heart rate. Alternative splicing results in multiple transcript variants, however, the full-length nature of some of these variants is not known. [provided by RefSeq, Sep 2015]

Rgs6 Products(6)

mRNA Protein Name
NM_001282061.3 NP_001268990.1 regulator of G-protein signaling 6 isoform 2
NM_001310478.3 NP_001297407.1 regulator of G-protein signaling 6 isoform 1
NM_001413651.1 NP_001400580.1 regulator of G-protein signaling 6 isoform 2
NM_001413652.1 NP_001400581.1 regulator of G-protein signaling 6 isoform 2
NM_001413653.1 NP_001400582.1 regulator of G-protein signaling 6 isoform 3
NM_015812.5 NP_056627.1 regulator of G-protein signaling 6 isoform 2
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15897264 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

regulator of G-protein signaling 6

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11924 RGS6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rgs6 NCBI NCBI:9628