2. Gene
  3. UIMC1 - ubiquitin interaction motif containing 1 Gene

UIMC1 - ubiquitin interaction motif containing 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Bos taurus

Also known as RAP80

Gene ID: 508607 | Gene type: protein coding

About UIMC1

Summary

This gene encodes a member of the RAP80 family of proteins, which are characterized by two tandem ubiquitin-interacting motifs (UIMs). The encoded protein is a subunit of the BRCA1-A complex and functions to recruit this complex to sites of DNA double-strand breaks through its ability to bind poly-ubiquitin chains found at these sites. Homozygous knockout mice for this gene exhibit enhanced sensitivity to ionizing radiation and risk for B-cell lymphoma and impaired DNA double-strand break repair. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

UIMC1 Products(2)

mRNA Protein Name
NM_001038061.3 NP_001033150.2 BRCA1-A complex subunit RAP80 isoform 1
NM_001113222.2 NP_001106693.1 BRCA1-A complex subunit RAP80 isoform 2
Protein Preferred Names Protein Names

BRCA1-A complex subunit RAP80

receptor associated protein 80

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15447 UIMC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens UIMC1 NCBI NCBI:51720