IMPG2 - interphotoreceptor matrix proteoglycan 2 Gene

Homo sapiens

Also known as RP56; VMD5; IPM200; SPACRCAN

Gene ID: 50939 | Gene type: protein coding

About IMPG2

Cytogenetic location: 3q12.3 Genomic coordinates (GRCh38): 3:101,222,546-101,320,575 (from NCBI)

This gene has 1 transcript (splice variant), 250 orthologues, 1 paralogue and is associated with 6 phenotypes. Low expression observed in reference dataset.

Summary

The protein encoded by this gene binds chondroitin sulfate and hyaluronan and is a proteoglycan. The encoded protein plays a role in the organization of the interphotoreceptor matrix and may promote the growth and maintenance of the light-sensitive photoreceptor outer segment. Defects in this gene are a cause of retinitis pigmentosa type 56 and maculopathy, IMPG2-related.[provided by RefSeq, Mar 2011]

IMPG2 Products(1)

mRNA	Protein	Name
NM_016247.4	NP_057331.2	interphotoreceptor matrix proteoglycan 2 precursor

IMPG2 Protein Structure

SEA

0
200
400
600
800
1000
1241 a.a.

Protein Preferred Names

Protein Names

interphotoreceptor matrix proteoglycan 2

IPM 200

Related Diseases

Diseases

Alias

Macular Dystrophy, Vitelliform, 5

VMD5	Vitelliform Macular Dystrophy 5

Retinitis Pigmentosa 56

RP56	Maculopathy, Impg2-Related
MACLP-IMPG2	Retinitis Pigmentosa, Type 56

Macular Dystrophy, Vitelliform, 2

Best Macular Dystrophy	Juvenile-Onset Vitelliform Macular Dystrophy
VMD2	Bmd
Macular Degeneration, Polymorphic Vitelline	Best Vitelliform Macular Dystrophy
Best Disease	Early-Onset Vitelliform Macular Dystrophy
Best Vitelliform Macular Dystrophy, Multifocal	Bvmd
Polymorphic Vitelline Macular Degeneration	Vitelliform Macular Dystrophy Type 2
Vitelliform Macular Dystrophy 2	Vitelliform Macular Dystrophy, Early-Onset
Vitelliform Macular Dystrophy, Juvenile-Onset	Autosomal Recessive Bestrophinopathy
Retinopathy, Burgess-Black Type	Best'S Macular Dystrophy
Vmd	Vitelliform Macular Dystrophy

Vitelliform Macular Dystrophy

Best Disease	Juvenile-Onset Vitelliform Macular Dystrophy
Macular Dystrophy, Vitelliform	Best Macular Dystrophy
Vitelliform Dystrophy

Macular Dystrophy, Vitelliform, 3

Adult-Onset Vitelliform Macular Dystrophy	Avmd
Adult-Onset Foveomacular Vitelliform Dystrophy	Aofmd
VMD3	Vitelliform Macular Dystrophy, Adult-Onset
Foveomacular Dystrophy, Adult-Onset, With Or Without Choroidal Neovascularization	Foveomacular Dystrophy, Adult-Onset, With Choroidal Neovascularization
Adult-Onset Foveomacular Dystrophy	Vitelliform Macular Dystrophy 3
Foveomacular Dystrophy, Adult-Onset	Foveomacular Dystrophy, Adult-Onset
Aofmd	Macular Dystrophy, Vitelliform, Adult-Onset
Adult-Onset Foveomacular Dystrophy With Choroidal Neovascularization	Gass Disease
Pseudo-Best Disease	Pseudo-Vitelliform Macular Dystrophy
Gas

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Eye Disease

Eye Diseases	Abnormality Of The Eye
Toxoplasma Oculopathy

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy	CORD2
Cone-Rod Retinal Dystrophy	Rcrd2
Cone-Rod Retinal Dystrophy 2	Crd2
Cord	Crd
Retinal Cone-Rod Dystrophy	Cone-Rod Retinal Dystrophy-2
Retinal Cone-Rod Dystrophy 2	Tapetoretinal Degeneration
Cone-Rod Degeneration	Cone Rod Dystrophy
Dystrophy, Cone-Rod	Dystrophy, Cone-Rod, Type 2
Retinitis Pigmentosa	Retinitis Pigmentosa 2
Progressive Cone-Rod Dystrophy

Solar Retinopathy

Solar Retinitis

Retinal Disease

Retinal Diseases	Retinal Disorder
Retinal Disorders

Cone-Rod Dystrophy 9

CORD9	Dystrophy, Cone-Rod, Type 9
Retinitis Pigmentosa 9

Chromosome 3q13.31 Deletion Syndrome

3q13 Microdeletion Syndrome	Monosomy 3q13
Chromosome 3, Monosomy 3q13	Del(3)(Q13)

Vitreoretinochoroidopathy

Autosomal Dominant Vitreoretinochoroidopathy	Advirc
Vitreoretinochoroidopathy With Microcornea, Glaucoma, And Cataract	Vitreoretinochoroidopathy, Autosomal Dominant, With Nanophthalmos
Microcornea, Rod-Cone Dystrophy, Cataract, And Posterior Staphyloma 2	Vitreoretinochoroidopathy Dominant
VRCP	Vitreoretinochoroidopathy, Autosomal Dominant
Vrcp Autosomal Dominant	Vitreoretinochoroidopathy Autosomal Dominant With Nanophthalmos, Microcornea, Rod-Cone Dystrophy, Cataract And Posterior Staphyloma
Vitreoretinochoroidopathy With Microcornea-Glaucoma-Cataract

Bestrophinopathy, Autosomal Recessive

Bestrophinopathy	Autosomal Recessive Bestrophinopathy
ARB	Bestrophinopathies
Retinopathy, Burgess-Black Type	Retinopathy Burgess-Black Type

Macular Degeneration, Age-Related, 2

Age Related Macular Degeneration 2	ARMD2
Macular Degeneration, Senile	Maculopathy, Age-Related, 2
Macular Degeneration, Age-Related, 2, Susceptibility To	Macular Degeneration, Age-Related, Type 2

Retinitis Pigmentosa 89

RP89	Retinitis Pigmentosa, Type 89

Chronic Interstitial Cystitis

Chorioretinal Scar

Chorioretinal Cicatrix	Cicatrix Of Choroid
Choroid Scar	Macula Scar
Macular Scarring	Retinal Cicatrix
Retinal Scar

Retinitis Pigmentosa 88

RP88	Retinitis Pigmentosa, Type 88

Galactosemia Iii

Galactose Epimerase Deficiency	Gale Deficiency
Udp-Galactose-4-Epimerase Deficiency	Epimerase Deficiency Galactosemia
Galactosemia Type 3	Gale-D
Uridine Diphosphate Galactose-4-Epimerase Deficiency	GALAC3
Galactosemia 3	Generalized Uridine Diphosphate Galactose-4-Epimerase Deficiency
Erythrocyte Uridine Diphosphate Galactose-4-Epimerase Deficiency	Galactosemia Type Iii
Udp-Galactose-4'-Epimerase Deficiency	Generalized Galactose Epimerase Deficiency
Generalized Gale Deficiency	Generalized Gale-D
Generalized Udp-Galactose-4-Epimerase Deficiency	Generalized Epimerase Deficiency Galactosemia
Erythrocyte Galactose Epimerase Deficiency	Erythrocyte Gale Deficiency
Erythrocyte Gale-D	Erythrocyte Udp-Galactose-4-Epimerase Deficiency
Erythrocyte Epimerase Deficiency Galactosemia	Galactosemias
Classical Galactosemia	Udpglucose 4-Epimerase Deficiency Disease

Basal Laminar Drusen

Drusen Of Bruch Membrane	Drusen, Cuticular
Drusen, Early Adult-Onset, Grouped	Cuticular Drusen
Early Adult-Onset Grouped Drusen	BLD
Drusen Cuticular	Drusen Early Adult-Onset Grouped

Amme Complex

Alport Syndrome, Mental Retardation, Midface Hypoplasia, And Elliptocytosis	ATS-MR
Alport Syndrome-Intellectual Disability-Midface Hypoplasia-Elliptocytosis Syndrome	Chromosome Xq22.3 Telomeric Deletion Syndrome
Amme Syndrome	Alport Syndrome With Intellectual Disability, Midface Hypoplasia And Elliptocytosis

Enhanced S-Cone Syndrome

Goldmann-Favre Syndrome	ESCS
Favre Hyaloideoretinal Degeneration	Retinoschisis With Early Hemeralopia
Retinoschisis With Early Nyctalopia	Enhanced S Cone Syndrome
S-Cone Syndrome, Enhanced

Macular Degeneration, Age-Related, 1

Macular Degeneration	Age-Related Macular Degeneration
Macular Degeneration, Age-Related	Age Related Macular Degeneration
Age Related Macular Degeneration 1	ARMD1
Senile Macular Degeneration	Maculopathy, Age-Related, 1
Macular Degeneration, Age-Related, Reduced Risk Of	Age Related Maculopathy 1
Age Related Maculopathies	Age Related Maculopathy
Senile Macular Retinal Degeneration	Macular Degeneration Of Retina
Age-Related Maculopathy	Amd
Armd	Age-Related Maculopathy, Susceptibility To
Maculopathy Age-Related	Macular Degeneration, Age-Related, 1, Susceptibility To
Maculopathy, Age-Related	Macular Degeneration, Age-Related, Type 1
Macular Degeneration, Age-Related, 2

Sorsby Fundus Dystrophy

SFD	Fundus Dystrophy, Pseudoinflammatory, Of Sorsby
Sorsby'S Fundus Dystrophy	Macular Dystrophy, Hemorrhagic
Hemorrhagic Macular Dystrophy	Pseudoinflammatory Fundus Dystrophy Of Sorsby
Sorsby'S Pseudoinflammatory Macular Dystrophy	Sorsby Pseudoinflammatory Fundus Dystrophy
Dystrophy, Fundus, Sorsby

Stargardt Disease

Stargardt Disease 1	Stargardt Macular Dystrophy
Stargardt Disease-1	Juvenile Onset Macular Degeneration
Stargardt Macular Degeneration	Juvenile Macular Degeneration
Macular Dystrophy With Flecks, Type 1	Stgd
Fundus Flavimaculatus	Stargardt 1
Stargardts Disease

Cone Dystrophy

Retinal Cone Dystrophy	Dystrophy, Cone
Cone Dystrophy 3

Congenital Stationary Night Blindness

Night Blindness, Congenital Stationary	Congenital Essential Nyctalopia
Oguchi Disease	Blindness, Night, Stationary, Congenital

Leber Plus Disease

Leber Congenital Amaurosis	Lca
Leber'S Amaurosis	Leber'S Disease
Amaurosis Congenita Of Leber	Amaurosis Congenita Of Leber, Type 1
Lhon Plus Disease	Congenital Absence Of The Rods And Cones
Congenital Retinal Blindness	Crb
Congenital Amaurosis Of Retinal Origin	Leber'S Congenital Amaurosis
Leber Congenital Amaurosis 1	Leber'S Congenital Tapetoretinal Degeneration
Leber'S Congenital Tapetoretinal Dysplasia	Lca1
Leber Congenital Amaurosis Type 1	Retinal Blindness, Congenital
Amaurosis, Leber Congenital	Dysgenesis Neuroepithelialis Retinae
Hereditary Epithelial Dysplasia Of Retina	Hereditary Retinal Aplasia
Heredoretinopathia Congenitalis	Leber Abiotrophy
Leber Congenital Tapetoretinal Degeneration	Lebers Congenital Amaurosis
Optic Atrophy, Hereditary, Leber

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06801	IMPG2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	IMPG2	VGNC	VGNC:62919
Canis familiaris	IMPG2	VGNC	VGNC:42013
Mus musculus	IMPG2	MGD	MGI:3044955
Bos taurus	IMPG2	VGNC	VGNC:30190
Macaca mulatta	IMPG2	VGNC	VGNC:73622
Rattus norvegicus	IMPG2	RGD	RGD:708358

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